Skip to Main content Skip to Navigation
New interface
Journal articles

Fungal mediated innate immune memory, what have we learned?

Abstract : The binary classification of mammalian immune memory is now obsolete. Innate immune cells carry memory characteristics. The overall capacity of innate immune cells to remember and alter their responses is referred as innate immune memory and the induction of a non-specific memory resulting in an enhanced immune status is termed "trained immunity". Historically, trained immunity was first described as triggered by the human fungal pathogen Candida albicans. Since, numerous studies have accumulated and deciphered the main characteristics of trained immunity mediated by fungi and fungal components. This review aims at presenting the newly described aspect of memory in innate immunity with an emphasis on the historically fungal mediated one, covering the known molecular mechanisms associated with training. In addition, the review uncovers the numerous non-specific effect that β-glucans trigger in the context of infectious diseases and septicaemia, inflammatory diseases and cancer.
Complete list of metadata

Cited literature [67 references]  Display  Hide  Download
Contributor : Quintin Jessica Connect in order to contact the contributor
Submitted on : Tuesday, June 23, 2020 - 5:23:47 PM
Last modification on : Thursday, April 7, 2022 - 10:10:41 AM
Long-term archiving on: : Thursday, September 24, 2020 - 6:37:59 PM


Files produced by the author(s)


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License




Jessica Quintin. Fungal mediated innate immune memory, what have we learned?. Seminars in Cell and Developmental Biology, 2019, 89, pp.71-77. ⟨10.1016/j.semcdb.2018.05.023⟩. ⟨pasteur-02873918⟩



Record views


Files downloads