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Super-Enhancers in the Control of Cell Identity and Disease

Abstract : Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology would be afforded by knowing the constellation of factors that constitute these domains and by identifying super-enhancers across the spectrum of human cell types. We describe here the population of transcription factors, cofactors, chromatin regulators, and transcription apparatus occupying super-enhancers in embryonic stem cells and evidence that super-enhancers are highly transcribed. We produce a catalog of super-enhancers in a broad range of human cell types and find that super-enhancers associate with genes that control and define the biology of these cells. Interestingly, disease-associated variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, we find that cancer cells generate super-enhancers at oncogenes and other genes important in tumor pathogenesis. Thus, super-enhancers play key roles in human cell identity in health and in disease.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02871951
Contributor : Violaine Saint-André <>
Submitted on : Wednesday, June 17, 2020 - 1:43:40 PM
Last modification on : Thursday, July 16, 2020 - 5:48:29 PM

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Denes Hnisz, Brian j. Abraham, Tong ihn Lee, Ashley Lau, Violaine Saint-André, et al.. Super-Enhancers in the Control of Cell Identity and Disease. Cell, Elsevier, 2013, 155 (4), pp.934-947. ⟨10.1016/j.cell.2013.09.053⟩. ⟨pasteur-02871951⟩

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