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When the going gets tough: survival strategies and environmental signaling networks in Bacillus subtilis

Tarek Msadek 1, *
* Corresponding author
Abstract : Regulatory pathways involving two-component histidine kinase/response regulator proteins of Bacillus subtilis are highly interconnected and form a signal transduction network controlling stationary-phase adaptive responses. These include chemotaxis and motility, degradative enzyme synthesis, antibiotic production, natural competence for DNA uptake, and sporulation. Many of these responses are mutually exclusive, with different control levels involving protein-environment, protein-protein and protein-DNA interactions, allowing the bacteria to adapt rapidly to environmental changes.
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Contributor : Tarek Msadek <>
Submitted on : Tuesday, June 16, 2020 - 4:03:25 PM
Last modification on : Tuesday, July 28, 2020 - 4:26:43 PM

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Tarek Msadek. When the going gets tough: survival strategies and environmental signaling networks in Bacillus subtilis. Trends in Microbiology, Elsevier, 1999, 7 (5), pp.201-207. ⟨10.1016/S0966-842X(99)01479-1⟩. ⟨pasteur-02870328⟩

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