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Serum Aspergillus Galactomannan for the Management of Disseminated Histoplasmosis in AIDS

Sébastien Rivière 1 Blandine Denis 1 Marie-Elisabeth Bougnoux 2 Fanny Lanternier 1 Marc Lecuit 3, 1, 4 Olivier Lortholary 5, 1
1 Service des Maladies infectieuses et tropicales [CHU Necker]
2 Laboratoire de Microbiologie [AP-HP Necker]
3 CHU Necker - Enfants Malades [AP-HP]
4 UPD5 - Université Paris Descartes - Paris 5
5 CNRMA - Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire
Abstract : Disseminated histoplasmosis is an emerging infection in patients with cellular immune deficiency in non-endemic countries, caused by the migration from endemic regions and the development of travels. Diagnosis can be challenging in this context because rapid diagnostic tools such as Histoplasma antigen detection or appropriate molecular tools are generally unavailable, serology is often negative in immunosuppressed patients, and isolation of the fungus from cultures often takes several weeks. Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02870296
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Submitted on : Tuesday, June 16, 2020 - 3:54:23 PM
Last modification on : Thursday, September 3, 2020 - 5:06:47 AM

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Sébastien Rivière, Blandine Denis, Marie-Elisabeth Bougnoux, Fanny Lanternier, Marc Lecuit, et al.. Serum Aspergillus Galactomannan for the Management of Disseminated Histoplasmosis in AIDS. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2012, 87 (2), pp.303-305. ⟨10.4269/ajtmh.2012.12-0119⟩. ⟨pasteur-02870296⟩

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