Campylobacter coli cultured from the stools of a patient with immunoproliferative small intestinal disease

S. Coeuret (1) , A. de La Blanchardière (1) , V. Saguet-Rysanek (2) , S. Cheze (3) , M. Tavernier (4) , D. Arsène (5) , Alexis Criscuolo (6) , Sylvain Brisse (6) , M. Vergnaud (7) , R. Verdon (1) , M. Lecuit (8, 9, 10, 11)

1 Unité de Maladies Infectieuses et Tropicales [CHU Caen]
2 Département de Pathologie [CHU Caen]
3 Laboratoire d'Hématologie Biologique [CHU Caen]
4 Service de Chirurgie Viscérale et Digestive [CHU Caen]
5 CHU Caen
6 Génomique évolutive des Microbes / Microbial Evolutionary Genomics
7 Service de Microbiologie [CHU Caen]
8 Biologie des Infections - Biology of Infection
9 Hôpital Necker - Enfants Malades [AP-HP]
10 Service des Maladies infectieuses et tropicales [CHU Necker]
11 UPD5 - Université Paris Descartes - Paris 5

Campylobacter has been associated with immunoproliferative small intestinal disease (IPSID), on the basis of 16S rDNA sequencing, in situ hybridization, and immunohistochemistry. Here, for the first time, we have cultured Campylobacter from the stools of a patient with IPSID. Phenotypic analysis and whole genome sequencing identified Campylobacter coli. PCR on a IPSID tissue biopsy sample was positive for Campylobacter coli and negative for Campylobacter jejuni. These findings further support a causative role for Campylobacter in the development of IPSID.

Mots clés: a-Heavy-chain disease; Campylobacter; immunoproliferative small intestinal disease; IPSID; lymphoma

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Maladies infectieuses; Microbiologie et Parasitologie; Immunologie

S. Coeuret, A. de La Blanchardière, V. Saguet-Rysanek, S. Cheze, M. Tavernier, et al.. Campylobacter coli cultured from the stools of a patient with immunoproliferative small intestinal disease. Clinical Microbiology and Infection, 2014, 20 (9), pp.908-911. ⟨10.1111/1469-0691.12545⟩. ⟨pasteur-02869792⟩