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Journal articles
Mesenchymal perivascular cells in immunity and disease
Abstract : The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role in tissue homeostasis, immunity and inflammatory pathologies by multiple mechanisms, including vascular modulation, leucocyte migration, activation or survival in the perivascular space and differentiation into specialized 'effector' mesenchymal cells essential for tissue repair and immunity, such as myofibroblasts and lymphoid stromal cells. When dysregulated, these responses contribute to inflammatory and fibrotic diseases.
Cited literature [65 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02867428
Contributor : Lucie Peduto Connect in order to contact the contributor
Submitted on : Sunday, June 14, 2020 - 11:15:39 AM
Last modification on : Monday, November 22, 2021 - 5:54:02 PM
Contributor : Lucie Peduto Connect in order to contact the contributor
Submitted on : Sunday, June 14, 2020 - 11:15:39 AM
Last modification on : Monday, November 22, 2021 - 5:54:02 PM
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Mesenchymal perivascular cells...
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