Abstract : The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role in tissue homeostasis, immunity and inflammatory pathologies by multiple mechanisms, including vascular modulation, leucocyte migration, activation or survival in the perivascular space and differentiation into specialized 'effector' mesenchymal cells essential for tissue repair and immunity, such as myofibroblasts and lymphoid stromal cells. When dysregulated, these responses contribute to inflammatory and fibrotic diseases.
https://hal-pasteur.archives-ouvertes.fr/pasteur-02867428 Contributor : Lucie PedutoConnect in order to contact the contributor Submitted on : Sunday, June 14, 2020 - 11:15:39 AM Last modification on : Thursday, April 7, 2022 - 10:10:41 AM
Adam Benabid, Lucie Peduto. Mesenchymal perivascular cells in immunity and disease. Current Opinion in Immunology, Elsevier, 2020, Functional interaction of lymphocytes/leukocytes, 64, pp.50-55. ⟨10.1016/j.coi.2020.03.009⟩. ⟨pasteur-02867428⟩