Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

V Madelain (1) , C Passaes (2, 3) , A. Millet (4) , V. Avettand-Fenoel (4) , Ramsès Emeric Djidjou Demasse (5) , N Dereuddre-Bosquet (3) , R Le Grand (3) , C Rouzioux (4) , B Vaslin (3) , A Saez-Cirion (2) , J Guedj (1)

1 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
2 HIV, Inflammation et persistance - HIV, Inflammation and Persistence
3 IMVA-HB - Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes
4 EA 7327 - Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV)
5 UMR SAVE - Santé et agroécologie du vignoble

Modeling viral dynamics in SIV natural controller macaques predicts that viral control is primarily driven by the capability to establish an efficient cytotoxic response and the viral decline during control unravels distinct compartments of infected cells.

Domains: Life Sciences [q-bio]; Immunology

V Madelain, C Passaes, A. Millet, V. Avettand-Fenoel, Ramsès Emeric Djidjou Demasse, et al.. Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells. 2020. ⟨pasteur-02865372⟩