Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

V Madelain; C Passaes; A. Millet; V. Avettand-Fenoel; Ramsès Emeric Djidjou Demasse; N Dereuddre-Bosquet; R Le Grand; C Rouzioux; B Vaslin; A Saez-Cirion; J Guedj

doi:10.1101/2020.01.19.911594

Preprints, Working Papers, ...

Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

V Madelain ¹ C Passaes ^{2, 3} A. Millet ⁴ V. Avettand-Fenoel ⁴ Ramsès Emeric Djidjou Demasse ⁵ N Dereuddre-Bosquet ³ R Le Grand ³ C Rouzioux ⁴ B Vaslin ³ A Saez-Cirion ² J Guedj ¹

1 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution

2 HIV, Inflammation et persistance - HIV, Inflammation and Persistence

3 IMVA-HB - Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes

4 EA 7327 - Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV)

5 UMR SAVE - Santé et agroécologie du vignoble

Abstract : Modeling viral dynamics in SIV natural controller macaques predicts that viral control is primarily driven by the capability to establish an efficient cytotoxic response and the viral decline during control unravels distinct compartments of infected cells.

Document type :

Preprints, Working Papers, ...

Domain :

Life Sciences [q-bio] / Immunology

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02865372
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Submitted on : Thursday, June 11, 2020 - 4:49:10 PM
Last modification on : Monday, September 5, 2022 - 2:44:06 PM

Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

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Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

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