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Journal articles
Insights into Streptococcus agalactiae PI-2b pilus biosynthesis and role in adherence to host cells
Abstract : The core PI-2b pilus present in "hypervirulent" ST-17 Streptococcus agalactiae strains consists of three pilin subunits (Spb1, Ap1 and Ap2) assembled by sortase SrtC1 and cell-wall anchored by Srt2. Spb1 was shown to be the major pilin and Ap2 the anchor pilin. Ap1 is a putative adhesin. Two additional genes, orf and lep, are part of this operon. The contribution of Lep and Ap1 to the biogenesis of the PI-2b pilus was investigated. Concerning the role of PI-2b, we found that higher PI-2b expression resulted in higher adherence to human brain endothelial cells and higher phagocytosis by human THP1 macrophages.
Cited literature [19 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02863685
Contributor : Bruno Perichon Connect in order to contact the contributor
Submitted on : Wednesday, June 10, 2020 - 2:45:04 PM
Last modification on : Wednesday, May 11, 2022 - 5:08:06 PM
Contributor : Bruno Perichon Connect in order to contact the contributor
Submitted on : Wednesday, June 10, 2020 - 2:45:04 PM
Last modification on : Wednesday, May 11, 2022 - 5:08:06 PM
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