Marokko hat in den letzten Jahrzehnten eine Drift von zirkulierenden Hepatitis-C-Virus-Subtypen erlebt - Archive ouverte HAL Access content directly
Journal Articles Archives of Virology Year : 2012

Marokko hat in den letzten Jahrzehnten eine Drift von zirkulierenden Hepatitis-C-Virus-Subtypen erlebt

Morocco underwent a drift of circulating hepatitis C virus subtypes in recent decades

Le Maroc a subi une dérive des sous-types de virus de l'hépatite C en circulation au cours des dernières décennies

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Abstract

Hepatitis C virus (HCV) isolates circulating in Morocco are poorly documented. To determine the subgenotype distribution of HCV in chronically infected patients, serum samples from 185 anti-HCV-positive patients were analyzed. Determination of the HCV genotype and subtype was performed by sequencing the 5'UTR, NS5B and core regions. According to the NS5B phylogeny, the HCV strains primarily belonged to subtypes 1b (75.2%), 2i (19.1%) and 2k (2.8%). Using a Bayesian approach, the mean date of appearance of the most recent common ancestor was estimated to be 1910 for HCV-1b and 1854 for HCV-2i. Although it is currently the most frequent genotype in Morocco and the dominant form in hepatocellular carcinoma, it thus appears that HCV-1b was introduced into the population subsequently to HCV-2i.

Dates and versions

pasteur-02863328 , version 1 (10-06-2020)

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Ikram Brahim, Abdelah Akil, El Mostafa Mtairag, Régis Pouillot, Abdelouhad El Malki, et al.. Morocco underwent a drift of circulating hepatitis C virus subtypes in recent decades. Archives of Virology, 2012, 157 (3), pp.515-520. ⟨10.1007/s00705-011-1193-7⟩. ⟨pasteur-02863328⟩
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