Immuno-modulatory functions of the type-3 secretion system and impacts on the pulmonary host defense: A role for ExoS of Pseudomonas aeruginosa in cystic fibrosis

Nawal Belmadi (1, 2) , Yongzheng Wu (3) , Lhousseine Touqui (1, 2)

1 EA 2511 - Mucoviscidose et bronchopathies chroniques : biopathologie et phénotypes cliniques
2 IP - Institut Pasteur [Paris]
3 Biologie cellulaire de l'Infection microbienne - Cellular Biology of Microbial Infection

Number of previous reviews had described the structures and the various functions of the exotoxins produced by the type-3 secretion system of Pseudomonas aeruginosa and their roles in the interactions of this bacterium with host cells. In this review, we summarize some relevant data of literature on ExoS, an exotoxin from the type-3 secretion system of P. aeruginosa, with a particular focus on the role of this toxin in the airways innate response of the host to infection by this bacterium, and its implication in the elimination of Staphylococcus aureus from the airways of patients with cystic fibrosis.

Keywords: Cystic fibrosis; Bacterial toxins; Phospholipase A2; Pseudomonas aeruginosa; Type-3 secretion system

Domains: Innate immunity; Infectious diseases; Pulmonology and respiratory tract; Bacteriology

Nawal Belmadi, Yongzheng Wu, Lhousseine Touqui. Immuno-modulatory functions of the type-3 secretion system and impacts on the pulmonary host defense: A role for ExoS of Pseudomonas aeruginosa in cystic fibrosis. Toxicon, 2018, 143, pp.68-73. ⟨10.1016/j.toxicon.2018.01.004⟩. ⟨pasteur-02863074⟩