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Type IIA Secreted Phospholipase A2 in Host Defense against Bacterial Infections

Abstract : The enzyme type IIA secreted phospholipase A2 (sPLA2-IIA) is crucial for mammalian innate host defense against bacterial pathogens. Most studies have investigated the role of sPLA2-IIA in systemic bacterial infections, identifying molecular pathways of bacterial resistance against sPLA2-IIA-mediated killing, and providing insight into sPLA2-IIA mechanisms of action. Sensitization of (antibiotic-resistant) bacteria to sPLA2-IIA action by blocking bacterial resistance or by applying sPLA2-IIA to treat bacterial infections might represent a therapeutic option in the future. Because sPLA2-IIA is highly expressed at mucosal barriers, we also discuss how sPLA2-IIA is likely to be an important driver of microbiome composition; we anticipate that future research in this area may bring new insights into the role of sPLA2-IIA in health and disease.
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Contributor : Yongzheng Wu <>
Submitted on : Tuesday, June 9, 2020 - 9:34:07 PM
Last modification on : Thursday, August 20, 2020 - 3:05:21 AM

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Vincent van Hensbergen, Yongzheng Wu, Nina van Sorge, Lhousseine Touqui. Type IIA Secreted Phospholipase A2 in Host Defense against Bacterial Infections. Trends in Immunology, Elsevier, 2020, 41 (4), pp.313-326. ⟨10.1016/j.it.2020.02.003⟩. ⟨pasteur-02863073⟩

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