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Neisseria meningitidis pili induce type-IIA phospholipase A 2 expression in alveolar macrophages

Abstract : Induction of type-IIA secreted phospholipase A2 (sPLA2-IIA) expression by bacterial components other than lipopolysaccharide has not been previously investigated. Here, we show that exposure of alveolar macrophages (AM) to Neisseria meningitidis or its lipooligosaccharide (LOS) induced sPLA2-IIA synthesis. However, N. meningitidis mutant devoid of LOS did not abolish this effect. In addition, a pili-defective mutant exhibited significantly lower capacity to stimulate sPLA2-IIA synthesis than the wild-type strain. Moreover, pili isolated from a LOS-defective strain induced sPLA2-IIA expression and nuclear factor kappa B (NF-kappaB) activation. These data suggest that pili are potent inducers of sPLA2-IIA expression by AM, through a NF-kappaB-dependent process.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02863049
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Submitted on : Tuesday, June 9, 2020 - 8:43:14 PM
Last modification on : Thursday, August 13, 2020 - 3:30:44 PM

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Lhousseine Touqui, Miguel Paya, Francoise Thouron, Annie Guiyoule, Maria-Leticia Zarantonelli, et al.. Neisseria meningitidis pili induce type-IIA phospholipase A 2 expression in alveolar macrophages. FEBS Letters, Wiley, 2005, 579 (22), pp.4923-4927. ⟨10.1016/j.febslet.2005.06.067⟩. ⟨pasteur-02863049⟩

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