Analogues structuraux de la serotonine comme marqueurs d'affinite des recepteurs serotoninergiques

T Huynh-Dinh (1) , A. Namane (1) , F Babin (1) , J Igolen (1) , J.C Rousselle (2) , M.P Fillion (2) , G. Fillion (2)

1 Chimie Organique
2 Pharmacologie-Toxicologie

Derivatives of serotonine and bufotenine are synthesized as potential electrophilic or photoactivable labels for the serotoninergic sites. The most promising compound is the azidoethyl-3 indole derivative 13 which presents a high affinity for the site; the corresponding binding appears specific and irreversible after photoactivation.

Domaines: Chimie organique

T Huynh-Dinh, A. Namane, F Babin, J Igolen, J.C Rousselle, et al.. Analogues structuraux de la serotonine comme marqueurs d'affinite des recepteurs serotoninergiques. Tetrahedron Letters, 1985, 26 (37), pp.4443-4446. ⟨10.1016/S0040-4039(00)88925-X⟩. ⟨pasteur-02862205⟩