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Beneficial role of adipose‐derived mesenchymal stem cells from microfragmented fat in a murine model of duchenne muscular dystrophy

Adrien Bouglé 1, 2, 3 Pierre Rocheteau 4, 2 David Briand 2 David Hardy 2 Franck Verdonk 5, 4, 2 Carlo Tremolada 6 Mikael Hivelin 7, 8 Fabrice Chrétien 4, 8, 2, * 
* Corresponding author
1 SU - Sorbonne Université
2 Neuropathologie expérimentale - Experimental neuropathology
3 CHU Pitié-Salpêtrière [AP-HP]
4 Centre Hospitalier Sainte Anne [Paris]
5 SU FM - Sorbonne Université - Faculté de Médecine
6 Italian Image Institute (Milan)
7 Service de Chirurgie plastique, reconstructrice et esthétique [Pompidou]
8 HEGP - Hôpital Européen Georges Pompidou [APHP]
Abstract : Introduction: No etiologic therapy is available for Duchenne muscular dystrophy (DMD), but mesenchymal stem cells were shown to be effective in preclinical models of DMD. The objective of this study is to investigate the effect of microfragmented fat extracted on a murine model of DMD. Methods: Fat tissue was extracted from healthy human participants and injected IM into DMD mice. Histological analysis, cytokines, and force measurement were performed up to 4 weeks after injection. Results: Duchenne muscular dystrophy mice injected with microfragmented fat exhibited an improved muscle phenotype (decreased necrosis and fibrosis), a decrease of inflammatory cytokines, and increased strength. Discussion: Administration of microfragmented fat in key muscles may improve muscular phenotype in patients with DMD.
Keywords : Duchenne muscular dystrophy adipose-derived mesenchymal stem cells mesenchymal stem cells microfragmented fat stem cells
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02862165
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Submitted on : Tuesday, June 9, 2020 - 12:34:21 PM
Last modification on : Friday, May 20, 2022 - 11:06:33 AM

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PASTEUR | UNIV-PARIS5 | USPC | SORBONNE-UNIVERSITE | SU-MEDECINE | UNIV-PARIS

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Adrien Bouglé, Pierre Rocheteau, David Briand, David Hardy, Franck Verdonk, et al.. Beneficial role of adipose‐derived mesenchymal stem cells from microfragmented fat in a murine model of duchenne muscular dystrophy. Muscle & nerve. Supplement., 2019, 60 (3), pp.328-335. ⟨10.1002/mus.26614⟩. ⟨pasteur-02862165⟩

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