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Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4 + T cells

Abstract : Type I interferons (IFNs) have the dual ability to promote the development of the immune response and exert an anti-inflammatory activity. We analyzed the integrated effect of IFN-α, TCR signal strength, and CD28 costimulation on human CD4⁺ T-cell differentiation into cell subsets producing the anti- and proinflammatory cytokines IL-10 and IFN-γ. We show that IFN-α boosted TCR-induced IL-10 expression in activated peripheral CD45RA⁺CD4⁺ T cells and in whole blood cultures. The functional cooperation between TCR and IFN-α efficiently occurred at low engagement of receptors. Moreover, IFN-α rapidly cooperated with anti-CD3 stimulation alone. IFN-α, but not IL-10, drove the early development of type I regulatory T cells that were mostly IL-10⁺ Foxp3⁻ IFN-γ⁻ and favored IL-10 expression in a fraction of Foxp3⁺ T cells. Our data support a model in which IFN-α costimulates TCR toward the production of IL-10 whose level can be amplified via an autocrine feedback loop.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02862146
Contributor : Frederique Michel <>
Submitted on : Tuesday, June 9, 2020 - 12:32:17 PM
Last modification on : Friday, June 19, 2020 - 3:27:21 AM

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Béatrice Corre, Julie Perrier, Margueritte El Khouri, Silvia Cerboni, Sandra Pellegrini, et al.. Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4 + T cells. European Journal of Immunology, Wiley-VCH Verlag, 2013, 43 (10), pp.2730-2740. ⟨10.1002/eji.201242977⟩. ⟨pasteur-02862146⟩

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