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Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration

Abstract : During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical. CXCL12 activity has been shown to be heavily influenced by its binding to extracellular glycosaminoglycans (GAG) by modulating its presentation to its receptors and by generating haptotactic gradients. Although CXCL12 has been implicated in several phases of tissue repair, the influence of GAG binding under HS influencing conditions such as acute tissue destruction remains understudied.
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Submitted on : Tuesday, June 9, 2020 - 11:51:35 AM
Last modification on : Monday, June 15, 2020 - 7:01:16 PM

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David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Pamela Gasse, et al.. Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration. Skeletal Muscle, BioMed Central, 2019, 9 (1), pp.25. ⟨10.1186/s13395-019-0210-5⟩. ⟨pasteur-02861879⟩

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