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Journal articles
Molecular assays for antimalarial drug resistance surveillance: A target product profile
Christian Nsanzabana
1, *
Frederic Ariey
2, 3
Hans-Peter Beck
4, 5
Xavier Ding
1
Edwin Kamau
6, 7
Sanjeev Krishna
8
Eric Legrand
9
Naomi Lucchi
10
Olivo Miotto
11, 12, 13
Sidsel Nag
14, 15
Harald Noedl
16
Cally Roper
17
Philip Rosenthal
18
Henk Schallig
19
Steve Taylor
20
Sarah Volkman
21, 22, 23
Iveth Gonzalez
1
*
Corresponding author
19
Experimental parasitology [Amsterdam, Pays-Bas]
Department of Medical Microbiology [Academic Medical Center]
Christian Nsanzabana 1
Correspondent author
Frederic Ariey 2, 3
Author
Hans-Peter Beck 4, 5
Author
Xavier Ding 1
Author
Olivo Miotto 11, 12, 13
Author
Sidsel Nag 14, 15
Author
Harald Noedl 16
Author
Cally Roper 17
Author
Philip Rosenthal 18
Author
Henk Schallig 19
Author
Steve Taylor 20
Author
Sarah Volkman 21, 22, 23
Author
Iveth Gonzalez 1
Author
1
FIND - Foundation for Innovative New Diagnostics (Campus Biotech, 9 Chemin des Mines – 1202 Geneva, Switzerland - Switzerland)
2
IC UM3 (UMR 8104 / U1016) - Institut Cochin (22 rue Méchain, 75014 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1016 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8104 (France)
- UP - Université de Paris : UM 3 (85 boulevard Saint-Germain 75006 Paris - France)
3
Service de parasitologie-mycologie [CHU Cochin] (27 Rue du Faubourg Saint-Jacques, 75014 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Cochin [AP-HP] (27 Rue du Faubourg Saint-Jacques 75014 Paris - France)
4
MPI - Medical Parasitology and Infection Biology [Basel, Suisse] (Socinstrasse 57, 4051 Basel, Suisse - Switzerland)
- Swiss Tropical and Public Health Institute [Basel] (Socinstrasse 57, CH 4002, Basel - Switzerland)
5
Unibas - University of Basel (Petersplatz 1, P. O. Box
4001 Basel - Switzerland)
6
Walter Reed Army Institute of Research (503 Robert Grant Ave, Silver Spring, MD 20910, États-Unis - United States)
7
USAMRD-K - United States Army Medical Research Directorate [Kenya] (Kenya Medical Research Institute, P.O. Box 54840 00200 Off Mbagathi Road. Nairobi, Kenya. - Kenya)
8
Institute for Infection and Immunity [Londres, UK] (St George's, University of London, Cranmer Terrace, London SW17 0RE - United Kingdom)
- St George's, University of London (Cranmer Terrace, London SW17 0RE, Royaume-Uni - United Kingdom)
9
Génétique du paludisme et résistance - Malaria Genetics and Resistance (Département Parasites et insectes vecteurs
25-28 rue du Docteur Roux
75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
10
DPDM - Division of Parasitic Diseases and Malaria [Atlanta, GA, États-Unis] (United States)
- CDC - Centers for Disease Control and Prevention [Atlanta] (1600 Clifton Rd. GA 30333 Atlanta, GA - United States)
- Centers for Disease Control and Prevention (United States)
11
Mahidol Oxford Tropical Medicine Research Unit (420/6 Ratchawithi Road, Tungphyathai, Bangkok 10400 - Thailand)
- University of Oxford [Oxford] (Wellington Square, Oxford OX1 2JD - United Kingdom)
- Mahidol University [Bangkok] (999 Phuttamonthon 4 Road, Salaya, Nakhon Pathom 73170 Thailand - Thailand)
12
The Wellcome Trust Sanger Institute [Cambridge] (Hinxton, Cambridge CB10 1SA, UK - United Kingdom)
13
Big Data Institute (United Kingdom)
- University of Oxford [Oxford] (Wellington Square, Oxford OX1 2JD - United Kingdom)
14
Centre for Medical Parasitology [Copenhagen] (Maersk Tower 07-11, Panum Institute, Blegdamsvej 3B, 2200 Copenhagen N, Denmark - Denmark)
- Department of Immunology and Microbiology [Copenhagen] (Panum
Blegdamsvej 3B
DK-2200 Copenhagen N
Denmark - Denmark)
- Faculty of Health and Medical Sciences (Blegdamsvej 3B
DK-2200 Copenhagen N
Denmark - Denmark)
- KU - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark)
- Faculty of Health and Medical Sciences (Blegdamsvej 3B
DK-2200 Copenhagen N
Denmark - Denmark)
15
Department of Infectious Disease [Copenhague, Danemark] (Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø - Denmark)
- Rigshospitalet [Copenhagen] (Blegdamsvej 9
2100 Copenhagen - Denmark)
- Copenhagen University Hospital (Denmark)
16
Institute of Specific Prophylaxis and Tropical Medicine = Institut für Spezifische Prophylaxe und Tropenmedizin [Vienne, Autriche] (Institut für Spezifische Prophylaxe und Tropenmedizin, Kinderspitalgasse 15, A-1090 Wien - Austria)
- Medizinische Universität Wien = Medical University of Vienna (Spitalgasse 23, A-1090 Vienna - Austria)
17
LSHTM - London School of Hygiene and Tropical Medicine (Keppel Street
London
WC1E 7HT
- United Kingdom)
18
Department of Medicine [San Francisco] (University of California at San Francisco - United States)
- UCSF - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)
- University of California (United States)
19
Experimental parasitology [Amsterdam, Pays-Bas] (Academic Medical Center (AMC), Meibergdreef 9 1105 AZ Amsterdam - Netherlands)
- Department of Medical Microbiology [Academic Medical Center] (Amsterdam - Netherlands)
- AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (Meibergdreef 9 1105 AZ Amsterdam - Netherlands)
- UvA - University of Amsterdam [Amsterdam] (Spui 21 1012 WX Amsterdam - Netherlands)
- AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (Meibergdreef 9 1105 AZ Amsterdam - Netherlands)
20
Duke University Medical Center (2301 Erwin Rd, Durham, NC 27710 - United States)
21
IID - Department of Immunology and Infectious Diseases (665 Huntington Avenue, Boston, MA, 02115 - United States)
- Harvard T.H. Chan School of Public Health ( 677 Huntington Avenue, Boston, MA 02115 - United States)
22
BROAD INSTITUTE - Broad Institute of MIT and Harvard (Cambridge, MA 02142 - United States)
- HMS - Harvard Medical School [Boston] (25 Shattuck Street Boston, MA 02115 - United States)
- MIT - Massachusetts Institute of Technology (77 Massachusetts Ave, Cambridge, MA 02139 - United States)
- Massachusetts General Hospital [Boston] (55 Fruit Street Boston, MA 02114 - United States)
23
Simmons University [Boston, USA] (300 The Fenway
Boston, MA 02115 - United States)
Abstract : Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. However, procedures are not adequately harmonized to facilitate comparisons between sites. Here we describe the target product profiles for tests to analyse molecular markers associated with antimalarial drug resistance, discuss how use of current techniques can be standardised, and identify the requirements for an ideal product that would allow malaria endemic countries to provide useful spatial and temporal information on the spread of resistance.
Document type :
Journal articles
Complete list of metadata
https://hal-pasteur.archives-ouvertes.fr/pasteur-02735465
Contributor : Eric Legrand <>
Submitted on : Tuesday, June 2, 2020 - 4:05:06 PM
Last modification on : Wednesday, June 30, 2021 - 11:08:01 AM
Long-term archiving on: : Wednesday, December 2, 2020 - 3:10:06 PM
Contributor : Eric Legrand <>
Submitted on : Tuesday, June 2, 2020 - 4:05:06 PM
Last modification on : Wednesday, June 30, 2021 - 11:08:01 AM
Long-term archiving on: : Wednesday, December 2, 2020 - 3:10:06 PM
Licence
Distributed under a Creative Commons CC0 - Public Domain Dedication 4.0 International License
Identifiers
- HAL Id : pasteur-02735465, version 1
- DOI : 10.1371/journal.pone.0204347
- PUBMED : 30235327
- PUBMEDCENTRAL : PMC6147503
Citation
Christian Nsanzabana, Frederic Ariey, Hans-Peter Beck, Xavier Ding, Edwin Kamau, et al.. Molecular assays for antimalarial drug resistance surveillance: A target product profile. PLoS ONE, Public Library of Science, 2018, 13 (9), pp.e0204347. ⟨10.1371/journal.pone.0204347⟩. ⟨pasteur-02735465⟩
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