Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

David Smadja (1, 2) , Coralie Guérin (1) , Richard Chocron (3, 4) , Nader Yatim (5, 6) , Jeremy Boussier (5, 6) , Nicolas Gendron (1, 2) , Lina Khider (2) , Jérôme Hadjadj (6, 7) , Guillaume Goudot (2) , Benjamin Debuc (8) , Philippe Juvin (4) , Caroline Hauw-Berlemont (9) , Jean-Loup Augy (9) , Nicolas Peron (9) , Emmanuel Messas (3, 10) , Benjamin Planquette (1, 2) , Olivier Sanchez (1, 2) , Bruno Charbit (11) , Pascale Gaussem (1, 12) , Darragh Duffy (5, 6) , Benjamin Terrier (3, 13) , Tristan Mirault (3, 2) , Jean-Luc Diehl (1, 9)

1 IThEM - U1140 - Innovations thérapeutiques en hémostase
2 Chirurgie Cardiovasculaire - Laboratoire de recherches biochirurgicales [AP-HP Hôpital Européen Georges Pompidou]
3 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
4 Emergency Department
5 Immunobiologie des Cellules dendritiques
6 Centre National de Référence Maladies auto-immunes Systémiques Rares [CHU Pitié-Salpêtrière]
7 Equipe Inserm U1163 - Immunogenetics of pediatric autoimmune diseases
8 Plastic Surgery Department [Paris]
9 Service de Pneumologie et Soins Intensifs [CHU HEGHP]
10 Service de médecine vasculaire et hypertension artérielle [CHU HEGP]
11 CRT - Centre de Recherche Translationnelle - Center for Translational Science
12 Service d'hématologie A [CHU HEGP]
13 Service de Médecine Interne [CHU HEGP]

Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis.

Keywords: Angiogenesis; Angiopoietin-2; Endothelial; COVID-19; Biomarker; E-selectin

Domains: Life Sciences [q-bio]; Immunology

David Smadja, Coralie Guérin, Richard Chocron, Nader Yatim, Jeremy Boussier, et al.. Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Angiogenesis, 2020, pp.1-10. ⟨10.1007/s10456-020-09730-0⟩. ⟨pasteur-02641638⟩