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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

William Nierman 1, 2, * Arnab Pain 3 Michael Anderson 4 Jennifer Wortman 2, 1 H Stanley Kim 2, 1 Javier Arroyo 5 Matthew Berriman 3 Keietsu Abe 6 David Archer 7 Clara Bermejo Joan Bennett Paul Bowyer 4 Dan Chen Matthew Collins 3 Richard Coulsen Robert Davies 3 Paul Dyer 7 Mark Farman 8 Nadia Fedorova Natalie Fedorova Tamara Feldblyum Reinhard Fischer Nigel Fosker Audrey Fraser 3 José García Maria García Arlette Goble Gustavo Goldman 9 Katsuya Gomi Sam Griffith-Jones Ryan Gwilliam Brian Haas Hubertus Haas 10 David Harris H. Horiuchi Jiaqi Huang Sean Humphray 3 Javier Jiménez Nancy Keller 11 Hoda Khouri Katsuhiko Kitamoto Tetsuo Kobayashi Sven Konzack Resham Kulkarni Toshitaka Kumagai Anne Lafton 12 Jean-Paul Latgé 13 Weixi Li Angela Lord Charles Lu William Majoros Gregory May Bruce Miller Yasmin Mohamoud Maria Molina Michel Monod 14 Isabelle Mouyna 13 Stephanie Mulligan Lee Murphy Susan O'Neil Ian Paulsen Miguel Peñalva Mihaela Pertea Claire Price Bethan Pritchard Michael Quail 3 Ester Rabbinowitsch 3 Neil Rawlins Marie-Adele Rajandream Utz Reichard Hubert Renauld Geoffrey Robson Santiago Rodriguez de Córdoba Jose Rodríguez-Peña Catherine Ronning Simon Rutter Steven Salzberg Miguel Sanchez Juan Sánchez-Ferrero David Saunders 3 Kathy Seeger Rob Squares Steven Squares Michio Takeuchi Fredj Tekaia 13 Geoffrey Turner Carlos Vázquez de Aldana Janice Weidman Owen White John Woodward Jae-Hyuk Yu 11 Claire Fraser James Galagan 15 Kiyoshi Asai 16 Masayuki Machida 16 Neil Hall 3 Bart Barrell 3 David Denning 4
* Corresponding author
1 GW - The George Washington University
2 Institute for Genome Sciences [Baltimore]
3 The Wellcome Trust Sanger Institute [Cambridge]
4 University of Manchester [Manchester]
5 UCM - Universidad Complutense de Madrid [Madrid]
6 Tohoku University [Sendai]
7 UON - University of Nottingham, UK
8 University of Kentucky
9 Faculdade de Ciências Farmacêuticas de Ribeirão Preto [São Paulo]
10 IMU - Innsbruck Medical University [Austria]
11 University of Wisconsin-Madison
12 Biologie et Pathogénicité fongiques
13 Aspergillus
14 CHUV - Centre Hospitalier Universitaire Vaudois [Lausanne]
15 BROAD INSTITUTE - Broad Institute of MIT and Harvard
16 AIST - National Institute of Advanced Industrial Science and Technology
Abstract : Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus.
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William Nierman, Arnab Pain, Michael Anderson, Jennifer Wortman, H Stanley Kim, et al.. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature, Nature Publishing Group, 2005, 438 (7071), pp.1151-1156. ⟨10.1038/nature04332⟩. ⟨pasteur-02639869⟩

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