Skip to Main content Skip to Navigation
Journal articles

Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals

Abstract : HIV-1 infection is associated with B cell dysregulation and dysfunction. In HIV-1-infected patients, we previously reported preservation of intestinal lymphoid structures and dendritic cell maturation pathways after early combination antiretroviral therapy (e-ART), started during the acute phase of the infection, compared with late combination antiretroviral therapy started during the chronic phase. In this study, we investigated whether the timing of combination antiretroviral therapy initiation was associated with the development of the HIV-1-specific humoral response in the gut. The results showed that e-ART was associated with higher frequencies of functional resting memory B cells in the gut. These frequencies correlated strongly with those of follicular Th cells in the gut. Importantly, frequencies of HIV-1 Env gp140-reactive B cells were higher in patients given e-ART, in whom gp140-reactive IgG production by mucosal B cells increased after stimulation. Moreover, IL-21 release by PBMCs stimulated with HIV-1 peptide pools was greater with e-ART than with late combination antiretroviral therapy. Thus, early treatment initiation helps to maintain HIV-1-reactive memory B cells in the gut as well as follicular Th cells, whose role is crucial in the development of potent affinity-matured and broadly neutralizing Abs.
Document type :
Journal articles
Complete list of metadatas

Cited literature [87 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02634634
Contributor : Valérie Lorin <>
Submitted on : Wednesday, June 10, 2020 - 10:00:24 AM
Last modification on : Wednesday, August 19, 2020 - 11:19:08 AM

File

paper_Planchais_B_cells_JI-rev...
Files produced by the author(s)

Identifiers

Collections

Citation

Cyril Planchais, Laurent Hocqueloux, Clara Ibanez, Sébastien Gallien, Christiane Copie, et al.. Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩. ⟨pasteur-02634634⟩

Share

Metrics

Record views

31

Files downloads

58