Differentiation of effector CD4 T cell populations (*), Annu. Rev. Immunol, vol.28, pp.445-489, 2010. ,
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity, vol.24, pp.179-189, 2006. ,
Transforming growth factor-beta induces development of the T(H)17 lineage, Nature, vol.441, pp.231-234, 2006. ,
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis, J. Exp. Med, vol.203, pp.1685-1691, 2006. ,
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells, Nature, vol.448, pp.480-483, 2007. ,
Epigenetics: a landscape takes shape, Cell, vol.128, pp.635-638, 2007. ,
Chromatin modifications and their function, Cell, vol.128, pp.693-705, 2007. ,
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells, Immunity, vol.30, pp.155-167, 2009. ,
Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation, J. Biol. Chem, vol.282, pp.5969-5972, 2007. ,
The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes, Prog. Nucleic Acid Res. Mol. Biol, vol.69, pp.205-247, 2001. ,
Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis, Proc. Natl Acad. Sci. USA, vol.97, pp.10132-10137, 2000. ,
Requirement for RORgamma in thymocyte survival and lymphoid organ development, Science, vol.288, pp.2369-2373, 2000. ,
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells, Nat. Immunol, vol.5, pp.64-73, 2004. ,
Down-regulation of the orphan nuclear receptor ROR?t is essential for T lymphocyte maturation, J. Immunol, vol.164, pp.5668-5674, 2000. ,
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, vol.126, pp.1121-1133, 2006. ,
, NATURE COMMUNICATIONS |, vol.10, p.4698, 2019.
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome, Nature, vol.452, pp.773-776, 2008. ,
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3, J. Exp. Med, vol.205, pp.1551-1557, 2008. ,
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells, J. Biol. Chem, vol.282, pp.9358-9363, 2007. ,
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis, Immunity, vol.32, pp.605-615, 2010. ,
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1, Cell, vol.146, pp.772-784, 2011. ,
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via ROR?t induction as downstream targets of Stat3, J. Exp. Med, vol.211, pp.1857-1874, 2014. ,
The Th17 immune response is controlled by the Rel-ROR?-ROR? T transcriptional axis, J. Exp. Med, vol.208, pp.2321-2333, 2011. ,
Interplay between ROR?t, Egr3, and E proteins controls proliferation in response to Pre-TCR signals, Immunity, vol.24, pp.813-826, 2006. ,
Transcription of ROR?t in developing Th17 cells is regulated by E-proteins, Mucosal Immunol, vol.7, pp.521-532, 2014. ,
Upstream stimulating factors regulate the expression of ROR T in human lymphocytes, J. Immunol, vol.189, pp.3034-3042, 2012. ,
Cell-specific gene promoters are marked by broader spans of H3K4me3 and are associated with robust gene expression patterns, Epigenomics, vol.7, pp.129-131, 2015. ,
Modification of enhancer chromatin: what, how, and why?, Mol. Cell, vol.49, pp.825-837, 2013. ,
Transcriptional regulation of Th17 cell differentiation, Semin. Immunol, vol.19, pp.409-417, 2007. ,
Transcription factors of the NFAT family: regulation and function, Annu. Rev. Immunol, vol.15, pp.707-747, 1997. ,
Transcriptional regulation by calcium, calcineurin, and NFAT, Genes Dev, vol.17, pp.2205-2232, 2003. ,
Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation, J. Immunol, vol.192, pp.110-122, 2014. ,
Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation, Mol. Cell. Biol, vol.15, pp.6299-6310, 1995. ,
Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP), J. Exp. Med, vol.187, pp.2031-2036, 1998. ,
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12, Immunity, vol.13, pp.715-725, 2000. ,
Transcript imaging of the development of human T helper cells using oligonucleotide arrays, Nat. Genet, vol.25, pp.96-101, 2000. ,
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses, Hum. Immunol, vol.74, pp.574-585, 2013. ,
Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-?-induced signaling in human monocytes, Gastroenterology, vol.144, p.10, 2013. ,
Small-molecule ROR?t antagonists Inhibit T Helper 17 cell transcriptional network by divergent mechanisms, Immunity, vol.40, pp.477-489, 2014. ,
Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets, J. Immunol, vol.160, pp.2324-2333, 1998. ,
Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint, J. Immunol. Baltim. Md, vol.179, pp.4694-4703, 1950. ,
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice, Immunity, vol.4, pp.397-405, 1996. ,
NFATc1 and NFATc2 together control both T and B cell activation and differentiation, Immunity, vol.14, pp.13-20, 2001. ,
Regulation of the murine Nfatc1 gene by NFATc2, J. Biol. Chem, vol.277, pp.10704-10711, 2002. ,
NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms, Eur. J. Immunol, vol.45, pp.1377-1389, 2015. ,
NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis, Eur. J. Immunol, vol.45, pp.1426-1440, 2015. ,
Differential expression of interleukin-17A and -17F Is Coupled to T cell receptor signaling via Inducible T cell kinase, Immunity, vol.31, pp.587-597, 2009. ,
Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis, Proc. Natl Acad. Sci. USA, vol.107, pp.15169-15174, 2010. ,
Identification of novel nuclear factor of activated T Cell (NFAT)-associated proteins in T cells, J. Biol. Chem, vol.291, pp.24172-24187, 2016. ,
Runx3 specifies lineage commitment of innate lymphoid cells, Nat. Immunol, vol.16, pp.1124-1133, 2015. ,
TGF-? converts Th1 cells into Th17 cells through stimulation of Runx1 expression, Eur. J. Immunol, vol.45, pp.1010-1018, 2015. ,
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding ROR?t, Nat. Immunol, vol.12, pp.96-104, 2011. ,
The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4, Cell, vol.85, pp.973-983, 1996. ,
A validated regulatory network for Th17 cell specification, Cell, vol.151, pp.289-303, 2012. ,
The AP-1 transcription factor Batf controls TH17 differentiation, Nature, vol.460, pp.405-409, 2009. ,
Calcineurin sets the bandwidth for discrimination of signals during thymocyte development, Nature, vol.450, pp.731-735, 2007. ,
The transcription factor NFAT4 is involved in the generation and survival of T cells, Immunity, vol.9, pp.295-304, 1998. ,
Chromatin priming elements establish immunological memory in T cells without activating transcription: T cell memory is maintained by DNA elements which stably prime inducible genes without activating steady state transcription, BioEssays, vol.39, p.1600184, 2017. ,
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation, Immunity, vol.9, pp.765-775, 1998. ,
Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow, J. Immunol. Methods, vol.311, pp.117-129, 2006. ,
Simultaneous assessment of NF-?B/p65 phosphorylation and nuclear localization using imaging flow cytometry, J. Immunol. Methods, vol.423, pp.3-11, 2015. ,
Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination, J. Immunol. Methods, vol.451, pp.71-77, 2017. ,
Standardized whole-blood transcriptional profiling enables the deconvolution of complex induced immune responses, Cell Rep, vol.16, pp.2777-2791, 2016. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01367555