J. Zhu, H. Yamane, and W. E. Paul, Differentiation of effector CD4 T cell populations (*), Annu. Rev. Immunol, vol.28, pp.445-489, 2010.

M. Veldhoen, R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger, TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity, vol.24, pp.179-189, 2006.

P. R. Mangan, Transforming growth factor-beta induces development of the T(H)17 lineage, Nature, vol.441, pp.231-234, 2006.

C. Sutton, C. Brereton, B. Keogh, K. H. Mills, and E. C. Lavelle, A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis, J. Exp. Med, vol.203, pp.1685-1691, 2006.

R. Nurieva, Essential autocrine regulation by IL-21 in the generation of inflammatory T cells, Nature, vol.448, pp.480-483, 2007.

A. D. Goldberg, C. D. Allis, and E. Bernstein, Epigenetics: a landscape takes shape, Cell, vol.128, pp.635-638, 2007.

T. Kouzarides, Chromatin modifications and their function, Cell, vol.128, pp.693-705, 2007.

G. Wei, Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells, Immunity, vol.30, pp.155-167, 2009.

A. M. Akimzhanov, X. O. Yang, and C. Dong, Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation, J. Biol. Chem, vol.282, pp.5969-5972, 2007.

A. M. Jetten, S. Kurebayashi, and E. Ueda, The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes, Prog. Nucleic Acid Res. Mol. Biol, vol.69, pp.205-247, 2001.

S. Kurebayashi, Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis, Proc. Natl Acad. Sci. USA, vol.97, pp.10132-10137, 2000.

Z. Sun, Requirement for RORgamma in thymocyte survival and lymphoid organ development, Science, vol.288, pp.2369-2373, 2000.

G. Eberl, An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells, Nat. Immunol, vol.5, pp.64-73, 2004.

Y. He, Down-regulation of the orphan nuclear receptor ROR?t is essential for T lymphocyte maturation, J. Immunol, vol.164, pp.5668-5674, 2000.

I. I. Ivanov, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, vol.126, pp.1121-1133, 2006.

, NATURE COMMUNICATIONS |, vol.10, p.4698, 2019.

J. D. Milner, Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome, Nature, vol.452, pp.773-776, 2008.

C. S. Ma, Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3, J. Exp. Med, vol.205, pp.1551-1557, 2008.

X. O. Yang, STAT3 regulates cytokine-mediated generation of inflammatory helper T cells, J. Biol. Chem, vol.282, pp.9358-9363, 2007.

L. Durant, Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis, Immunity, vol.32, pp.605-615, 2010.

E. V. Dang, Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1, Cell, vol.146, pp.772-784, 2011.

S. Tanaka, Sox5 and c-Maf cooperatively induce Th17 cell differentiation via ROR?t induction as downstream targets of Stat3, J. Exp. Med, vol.211, pp.1857-1874, 2014.

Q. Ruan, The Th17 immune response is controlled by the Rel-ROR?-ROR? T transcriptional axis, J. Exp. Med, vol.208, pp.2321-2333, 2011.

H. Xi, R. Schwartz, I. Engel, C. Murre, and G. J. Kersh, Interplay between ROR?t, Egr3, and E proteins controls proliferation in response to Pre-TCR signals, Immunity, vol.24, pp.813-826, 2006.

F. Zhang, I. J. Fuss, Z. Yang, and W. Strober, Transcription of ROR?t in developing Th17 cells is regulated by E-proteins, Mucosal Immunol, vol.7, pp.521-532, 2014.

M. Ratajewski, A. Walczak-drzewiecka, A. Salkowska, and J. Dastych, Upstream stimulating factors regulate the expression of ROR T in human lymphocytes, J. Immunol, vol.189, pp.3034-3042, 2012.

D. Ucar and D. Bayarsaihan, Cell-specific gene promoters are marked by broader spans of H3K4me3 and are associated with robust gene expression patterns, Epigenomics, vol.7, pp.129-131, 2015.

E. Calo and J. Wysocka, Modification of enhancer chromatin: what, how, and why?, Mol. Cell, vol.49, pp.825-837, 2013.

I. I. Ivanov, L. Zhou, and D. R. Littman, Transcriptional regulation of Th17 cell differentiation, Semin. Immunol, vol.19, pp.409-417, 2007.

A. Rao, C. Luo, and P. G. Hogan, Transcription factors of the NFAT family: regulation and function, Annu. Rev. Immunol, vol.15, pp.707-747, 1997.

P. G. Hogan, L. Chen, J. Nardone, and A. Rao, Transcriptional regulation by calcium, calcineurin, and NFAT, Genes Dev, vol.17, pp.2205-2232, 2003.

K. Kim, Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation, J. Immunol, vol.192, pp.110-122, 2014.

J. W. Rooney, Y. L. Sun, L. H. Glimcher, and T. Hoey, Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation, Mol. Cell. Biol, vol.15, pp.6299-6310, 1995.

C. García-rodríguez and A. Rao, Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP), J. Exp. Med, vol.187, pp.2031-2036, 1998.

B. Oppmann, Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12, Immunity, vol.13, pp.715-725, 2000.

L. Rogge, Transcript imaging of the development of human T helper cells using oligonucleotide arrays, Nat. Genet, vol.25, pp.96-101, 2000.

T. Vang, The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses, Hum. Immunol, vol.74, pp.574-585, 2013.

M. R. Spalinger, Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-?-induced signaling in human monocytes, Gastroenterology, vol.144, p.10, 2013.

S. Xiao, Small-molecule ROR?t antagonists Inhibit T Helper 17 cell transcriptional network by divergent mechanisms, Immunity, vol.40, pp.477-489, 2014.

Y. Amasaki, E. S. Masuda, R. Imamura, K. Arai, and N. Arai, Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets, J. Immunol, vol.160, pp.2324-2333, 1998.

E. K. Koltsova, Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint, J. Immunol. Baltim. Md, vol.179, pp.4694-4703, 1950.

M. R. Hodge, Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice, Immunity, vol.4, pp.397-405, 1996.

S. L. Peng, A. J. Gerth, A. M. Ranger, and L. H. Glimcher, NFATc1 and NFATc2 together control both T and B cell activation and differentiation, Immunity, vol.14, pp.13-20, 2001.

B. Zhou, Regulation of the murine Nfatc1 gene by NFATc2, J. Biol. Chem, vol.277, pp.10704-10711, 2002.

L. Dietz, NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms, Eur. J. Immunol, vol.45, pp.1377-1389, 2015.

S. Reppert, NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis, Eur. J. Immunol, vol.45, pp.1426-1440, 2015.

J. Gomez-rodriguez, Differential expression of interleukin-17A and -17F Is Coupled to T cell receptor signaling via Inducible T cell kinase, Immunity, vol.31, pp.587-597, 2009.

S. Ghosh, Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis, Proc. Natl Acad. Sci. USA, vol.107, pp.15169-15174, 2010.

C. H. Gabriel, Identification of novel nuclear factor of activated T Cell (NFAT)-associated proteins in T cells, J. Biol. Chem, vol.291, pp.24172-24187, 2016.

T. Ebihara, Runx3 specifies lineage commitment of innate lymphoid cells, Nat. Immunol, vol.16, pp.1124-1133, 2015.

H. Liu, TGF-? converts Th1 cells into Th17 cells through stimulation of Runx1 expression, Eur. J. Immunol, vol.45, pp.1010-1018, 2015.

V. Lazarevic, T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding ROR?t, Nat. Immunol, vol.12, pp.96-104, 2011.

I. C. Ho, M. R. Hodge, J. W. Rooney, and L. H. Glimcher, The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4, Cell, vol.85, pp.973-983, 1996.

M. Ciofani, A validated regulatory network for Th17 cell specification, Cell, vol.151, pp.289-303, 2012.

B. U. Schraml, The AP-1 transcription factor Batf controls TH17 differentiation, Nature, vol.460, pp.405-409, 2009.

E. M. Gallo, Calcineurin sets the bandwidth for discrimination of signals during thymocyte development, Nature, vol.450, pp.731-735, 2007.

M. Oukka, The transcription factor NFAT4 is involved in the generation and survival of T cells, Immunity, vol.9, pp.295-304, 1998.

S. L. Bevington, P. Cauchy, and P. N. Cockerill, Chromatin priming elements establish immunological memory in T cells without activating transcription: T cell memory is maintained by DNA elements which stably prime inducible genes without activating steady state transcription, BioEssays, vol.39, p.1600184, 2017.

S. Agarwal and A. Rao, Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation, Immunity, vol.9, pp.765-775, 1998.

T. C. George, Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow, J. Immunol. Methods, vol.311, pp.117-129, 2006.

O. Maguire, K. O'loughlin, and H. Minderman, Simultaneous assessment of NF-?B/p65 phosphorylation and nuclear localization using imaging flow cytometry, J. Immunol. Methods, vol.423, pp.3-11, 2015.

H. Lenden-hasse, Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination, J. Immunol. Methods, vol.451, pp.71-77, 2017.

A. Urrutia, Standardized whole-blood transcriptional profiling enables the deconvolution of complex induced immune responses, Cell Rep, vol.16, pp.2777-2791, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01367555