Orthogonal Genetic Systems - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue ChemBioChem Année : 2020

Orthogonal Genetic Systems

Résumé

Xenobiology is an emerging area of synthetic biology that aims to safeguard genetically engineered cells by storing synthetic biology information in xeno-nucleic acid polymers (XNAs). Critical to the success of this effort is the need to establish cellular systems that can maintain an XNA chromosome in actively dividing cells. This viewpoint discusses the structural parameters of the nucleic acid backbone that should be considered when designing an orthogonal genetic system that can replicate without interference from the endogenous genome. In addition to practical value, these studies have the potential to provide new fundamental insight into the structure and function properties of unnatural nucleic acid polymers.

Domaines

Chimie organique
Fichier principal
Vignette du fichier
Orthogonal Genetic Systems_Revised.pdf (968.27 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

pasteur-02625660 , version 1 (06-07-2020)

Identifiants

Citer

John Chaput, Piet Herdewijn, Marcel Hollenstein. Orthogonal Genetic Systems. ChemBioChem, 2020, 21 (10), pp.1408-1411. ⟨10.1002/cbic.201900725⟩. ⟨pasteur-02625660⟩
104 Consultations
263 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More