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Prevention and control of meningococcal disease: Updates from the Global Meningococcal Initiative in Eastern Europe

Xilian Bai 1 Ray Borrow 1 Suzana Bukovski 2 Dominique Caugant 3 Davor Culic 4 Snezana Delic 4 Ener Cagri Dinleyici 5 Medeia Eloshvili 6 Tímea Erdősi 7 Jelena Galajeva 8 Pavla Křížová 9 Jay Lucidarme 10 Konstantin Mironov 11 Zuridin Nurmatov 12 Marina Pana 13 Erkin Rahimov 14 Larisa Savrasova 15 Anna Skoczyńska 16 Vinny Smith 17 Muhamed-Kheir Taha 18 Leonid Titov 19 Julio Vazquez 20 Lyazzat Yeraliyeva 21
Abstract : The Global Meningococcal Initiative (GMI) aims to prevent invasive meningococcal disease (IMD) worldwide through education, research and cooperation. In March 2019, a GMI meeting was held with a multidisciplinary group of experts and representatives from countries within Eastern Europe. Across the countries represented, IMD surveillance is largely in place, with incidence declining in recent decades and now generally at <1 case per 100,000 persons per year. Predominating serogroups are B and C, followed by A, and cases attributable to serogroups W, X and Y are emerging. Available vaccines differ between countries, are generally not included in immunization programs and provided to high-risk groups only. Available vaccines include both conjugate and polysaccharide vaccines; however, current data and GMI recommendations advocate the use of conjugate vaccines, where possible, due to the ability to interrupt the acquisition of carriage. Ongoing carriage studies are expected to inform vaccine effectiveness and immunization schedules. Additionally, IMD prevention and control should be guided by monitoring outbreak progression and the emergence and international spread of strains and antibiotic resistance through use of genomic analyses and implementation of World Health Organization initiatives. Protection of high-risk groups (such as those with complement deficiencies, laboratory workers, migrants and refugees) is recommended.
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Xilian Bai, Ray Borrow, Suzana Bukovski, Dominique Caugant, Davor Culic, et al.. Prevention and control of meningococcal disease: Updates from the Global Meningococcal Initiative in Eastern Europe. Journal of Infection, WB Saunders, 2019, 79 (6), pp.528-541. ⟨10.1016/j.jinf.2019.10.018⟩. ⟨pasteur-02618573⟩

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