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Journal articles
Development and validation of serological markers for detecting recent Plasmodium vivax infection
Rhea Longley
1, 2, 3
Michael White
4
Eizo Takashima
5
Jessica Brewster
1
Masayuki Morita
5
Thomas Obadia
4, 6
Leanne Robinson
1, 2, 7
Fumie Matsuura
8
Zoe Liu
1, 2
Connie Li-Wai-Suen
1, 2
Wai-Hong Tham
2, 1
Julie Healer
2, 1
Christèle Huon
9
Chetan Chitnis
9
Wang Nguitragool
3
Wuelton Monteiro
10, 11
Carla Proietti
12, 13
Denise Doolan
12, 13
Andre Siqueira
14
Xavier Ding
15
Iveth Gonzalez
15
James Kazura
16
Marcus Lacerda
17
Jetsumon Sattabongkot
3
Takafumi Tsuboi
5
Ivo Mueller
1, 2, 4, *
*
Corresponding author
Rhea J Longley 1, 2, 3
Author
Michael T White 4
Author
Eizo Takashima 5
Author
Jessica Brewster 1
Author
Masayuki Morita 5
Author
Thomas Obadia 4, 6
Author IdHAL : thomas-obadia
Leanne J Robinson 1, 2, 7
Author
Fumie Matsuura 8
Author
Zoe S J Liu 1, 2
Author
Connie S N Li-Wai-Suen 1, 2
Author
Wai-Hong Tham 2, 1
Author
Julie Healer 2, 1
Author
Christèle Huon 9
Author
Chetan E Chitnis 9
Author
Wang Nguitragool 3
Author
Wuelton Monteiro 10, 11
Author
Carla Proietti 12, 13
Author
Denise L Doolan 12, 13
Author
Andre M Siqueira 14
Author
Xavier Ding 15
Author
Iveth Gonzalez 15
Author
James Kazura 16
Author
Marcus Lacerda 17
Author
Jetsumon Sattabongkot 3
Author
Takafumi Tsuboi 5
Author
Ivo Mueller 1, 2, 4
Correspondent author
1
WEHI - The Walter and Eliza Hall Institute of Medical Research (1G Royal Parade Parkville Victoria 3052 - Australia)
2
University of Melbourne (Parkville VIC 3010 - Australia)
3
Mahidol University [Bangkok] (999 Phuttamonthon 4 Road, Salaya, Nakhon Pathom 73170 Thailand - Thailand)
4
Malaria : parasites et hôtes - Malaria : parasites and hosts (Département Parasites et Insectes Vecteurs
25-28, rue du Docteur Roux
75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
5
Ehime University [Matsuyama] (Matsuyama, Ehime Prefecture 790-8577, Japon - Japan)
6
Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB (C3BI, 25-28 rue du Docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : USR3756 (France)
7
Burnet Institute [Melbourne, Victoria] (85 Commercial Rd, Melbourne VIC 3004, Australie - Australia)
8
CellFree Sciences Co., Ltd. (Ehime University Academic Support Center Applied Protein Research Lab 4F, 3 Bunkyo-cho, Matsuyama, Ehime, 790-8577 JAPAN - Japan)
9
Biologie de Plasmodium et Vaccins (Département des Parasites et Insectes vecteurs, 25-28, rue du docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
10
FMT-HVD - Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (Av. Pedro Teixeira, 25 - Dom Pedro, Manaus - AM, Brésil - Brazil)
11
UEA - Universidade do Estado do Amazonas (Manaus, Amazonas - Brazil)
12
JCU - James Cook University (Australia)
13
Queensland Institute of Medical Research (Queensland Institute of Medical Research Locked Bag 2000 Royal Brisbane Hospital Herston, Qld 4029 Australia - Australia)
14
FIOCRUZ - Fundação Oswaldo Cruz (Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - Brazil)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
15
FIND - Foundation for Innovative New Diagnostics (Campus Biotech, 9 Chemin des Mines – 1202 Geneva, Switzerland - Switzerland)
16
Center for Global Health and Diseases (Cleveland, OH 44106-7286 - United States)
- School of Medicine (United States)
- Case Western Reserve University [Cleveland] (10900 Euclid Ave., Cleveland, Ohio 44106 - United States)
17
ILMD - Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (476 Teresina Street. Adrianópolis. Manaus - AM - Brazil)
- FIOCRUZ - Fundação Oswaldo Cruz (Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - Brazil)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
Abstract : A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02612720
Contributor : Thomas Obadia <>
Submitted on : Friday, May 29, 2020 - 2:16:27 PM
Last modification on : Friday, October 16, 2020 - 4:08:02 PM
Contributor : Thomas Obadia <>
Submitted on : Friday, May 29, 2020 - 2:16:27 PM
Last modification on : Friday, October 16, 2020 - 4:08:02 PM
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Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License
Identifiers
- HAL Id : pasteur-02612720, version 1
- DOI : 10.1038/s41591-020-0841-4
- PUBMED : 32405064
Citation
Rhea Longley, Michael White, Eizo Takashima, Jessica Brewster, Masayuki Morita, et al.. Development and validation of serological markers for detecting recent Plasmodium vivax infection. Nature Medicine, Nature Publishing Group, 2020, 26 (5), pp.741-749. ⟨10.1038/s41591-020-0841-4⟩. ⟨pasteur-02612720⟩
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