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Journal articles
Serpentine: a flexible 2D binning method for differential Hi-C analysis
Abstract : Hi-C contact maps reflect the relative contact frequencies between pairs of genomic loci, quantified through deep sequencing. Differential analyses of these maps enable downstream biological interpretations. However, the multi-fractal nature of the chromatin polymer inside the cellular envelope results in contact frequency values spanning several orders of magnitude: contacts between loci pairs at large genomic distances are much sparser than closer pairs. The same is true for poorly-covered regions such as repeated sequences. Both distant and poorly covered regions translate into low signal-to-noise ratios. There is no clear consensus to address this limitation.
Cited literature [21 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02612482
Contributor : Romain Koszul <>
Submitted on : Wednesday, July 22, 2020 - 3:55:54 PM
Last modification on : Wednesday, June 23, 2021 - 2:18:12 PM
Long-term archiving on: : Tuesday, December 1, 2020 - 5:13:34 AM
Contributor : Romain Koszul <>
Submitted on : Wednesday, July 22, 2020 - 3:55:54 PM
Last modification on : Wednesday, June 23, 2021 - 2:18:12 PM
Long-term archiving on: : Tuesday, December 1, 2020 - 5:13:34 AM
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