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Programmed cell death‐1 3′‐untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection

Abstract : Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T-cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single-nucleotide polymorphism in the 3'-untranslated region (3'-UTR) of PD-1, has been associated with susceptibility and disease progression of chronic HBV infection in far-eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD-1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse-transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P = 0.038) against HBV infection. Interestingly, PD-1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD-1 mRNA compared with corresponding genotypes in resolved subjects (P = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV-infected patients carrying PD-1 GG and GA genotypes at rs10204525 have high PD-1 mRNA expression and may be more prone to installation of chronicity.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02611937
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Submitted on : Monday, May 18, 2020 - 5:59:48 PM
Last modification on : Wednesday, October 28, 2020 - 2:24:01 PM

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Hajar Chihab, Fatima-Zahra Jadid, Pelagia Foka, Imane Zaidane, Raouia El Fihry, et al.. Programmed cell death‐1 3′‐untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection. Journal of Medical Virology, Wiley-Blackwell, 2018, 90 (11), pp.1730-1738. ⟨10.1002/jmv.25265⟩. ⟨pasteur-02611937⟩

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