Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients

Fatima Zahra Jadid (1, 2) , Hajar Chihab (1) , Hanane Salih Alj (2) , Raouia Elfihry (1) , Imane Zaidane (1) , Sanaa Tazi (1) , Wafaa Badre (3) , Agnès Marchio (4) , Kamal Marhoum El Filali (3) , Mohammed Tahiri (3) , Rachid Saile (2) , Pascal Pineau (4) , Sayeh Ezzikouri (1) , Soumaya Benjelloun (1)

1 Institut Pasteur du Maroc
2 UH2MC - Université Hassan II [Casablanca]
3 CHU Ibn Rochd [Casablanca]
4 Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis

Chronic Hepatitis C is one of the most important risk factors of liver cirrhosis and hepatocellular carcinoma. Before reaching these ultimate steps, insulin resistance triggered by hepatitis C virus infection is known to participate in the progression of liver disease. The present study aims to investigate the influence of two functional polymorphisms on SOCS3 mRNA expression and on the outcomes of CHC progression in a North African context.

Keywords: HCV infection; Polymorphism; SOCS3; mRNA expression

Domains: Life Sciences [q-bio]; Cancer

Fatima Zahra Jadid, Hajar Chihab, Hanane Salih Alj, Raouia Elfihry, Imane Zaidane, et al.. Control of progression towards liver fibrosis and hepatocellular carcinoma by SOCS3 polymorphisms in chronic HCV-infected patients. Infection, Genetics and Evolution, 2018, 66, pp.1-8. ⟨10.1016/j.meegid.2018.08.027⟩. ⟨pasteur-02611922⟩