Intrahepatic cholangiocarcinoma, Surg. Clin. North Am, vol.90, pp.817-837, 2010. ,
Cholangiocarcinomaevolving concepts and therapeutic strategies, Nat. Rev. Clin. Oncol, vol.15, pp.95-111, 2018. ,
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer, N. Engl. J. Med, vol.362, pp.1273-1281, 2010. ,
The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma, Nat. Rev. Gastroenterol. Hepatol, vol.9, pp.44-54, 2011. ,
Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting, Hepatol. Baltim. Md, vol.59, pp.2397-2402, 2014. ,
Nivolumab and Ipilimumab in Advanced Melanoma, N. Engl. J. Med, vol.377, pp.2503-2504, 2017. ,
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer, N. Engl. J. Med, vol.373, pp.123-135, 2015. ,
Pembrolizumab versus Ipilimumab in Advanced Melanoma, N. Engl. J. Med, vol.372, pp.2521-2532, 2015. ,
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial, Lancet Lond. Engl, vol.389, pp.2492-2502, 2017. ,
PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.22, pp.470-478, 2016. ,
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors, Gastroenterology, vol.142, p.15, 2012. ,
Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma, Hepatol. Baltim. Md, vol.56, pp.1792-1803, 2012. ,
Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes, Gastroenterology, vol.144, pp.829-840, 2013. ,
Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers, Accepted Article, vol.14, pp.1474-1478, 2013. ,
Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients, Gastroenterology, vol.146, pp.1397-1407, 2014. ,
Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma, PLoS Genet, vol.10, p.1004135, 2014. ,
Mutational landscape of intrahepatic cholangiocarcinoma, Nat. Commun, vol.5, p.5696, 2014. ,
, Lancet Lond. Engl, vol.383, pp.2168-2179, 2014.
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles, Cell Rep, vol.19, pp.2878-2880, 2017. ,
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma, Cancer Discov, vol.7, pp.1116-1135, 2017. ,
Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma, Hepatol. Baltim. Md, vol.59, pp.1427-1434, 2014. ,
An Immune Atlas of Clear Cell Renal Cell Carcinoma, Cell, vol.169, pp.736-749, 2017. ,
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq, Science, vol.352, pp.189-196, 2016. ,
Robust enumeration of cell subsets from tissue expression profiles, Nat. Methods, vol.12, pp.453-457, 2015. ,
DeconRNASeq: a statistical framework for deconvolution of heterogeneous tissue samples based on mRNA-Seq data, Bioinforma. Oxf. Engl, vol.29, pp.1083-1085, 2013. ,
Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression, Genome Biol, vol.17, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01398093
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol. Rev, vol.88, pp.125-172, 2008. ,
Hepatic stellate cells: partners in crime for liver metastases?, Hepatol. Baltim. Md, vol.54, pp.707-713, 2011. ,
Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins, J. Biol. Chem, vol.281, pp.16289-16295, 2006. ,
Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis, Gastroenterology, vol.154, pp.1009-1023, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02626272
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res, vol.20, pp.5064-5074, 2014. ,
Genomic spectra of biliary tract cancer, Nat. Genet, vol.47, pp.1003-1010, 2015. ,
Identification of cellular targets in human intrahepatic cholangiocarcinoma using laser microdissection and accurate mass and time tag proteomics ,
URL : https://hal.archives-ouvertes.fr/inserm-00515623
, Mol. Cell. Proteomics MCP, vol.9, 1991.
Epithelial-mesenchymal transition in cholangiocarcinoma: From clinical evidence to regulatory networks, J. Hepatol, vol.66, pp.424-441, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01377000
Pathologic classification of cholangiocarcinoma: New concepts, Best Pract Res Clin Gastroenterol, vol.29, pp.277-93, 2015. ,
Intrahepatic Cholangiocarcinomas Have Histologically and Immunophenotypically Distinct Small and Large Duct Patterns, Am J Surg Pathol, vol.42, pp.1334-1345, 2018. ,
Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance, J. Hepatol, vol.61, pp.1385-1396, 2014. ,
Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer, Cancer Immunol. Res, vol.4, pp.563-568, 2016. ,
WNT/?-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers, Clin. Cancer Res. Off ,
, J. Am. Assoc. Cancer Res, vol.25, pp.3074-3083, 2019.
The consensus molecular subtypes of colorectal cancer, Nat. Med, vol.21, pp.1350-1356, 2015. ,
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer ,
, Eur. Urol, 2019.
Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy, Clin. Cancer Res. Off. J. Am ,
, Cancer Res, 2016.
Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation via TGF-?, Cell. Mol. Gastroenterol. Hepatol, vol.2, pp.302-316, 2016. ,
Elements of cancer immunity and the cancer-immune set point, Nature, vol.541, pp.321-330, 2017. ,
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies, Nat. Rev. Drug Discov, 2019. ,
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models, Cancer Res, vol.74, pp.5057-5069, 2014. ,
, Accepted Article