Identification of four immune subtypes characterized by distinct composition and functions of tumor microenvironment in intrahepatic cholangiocarcinoma

Sylvie Job (1) , Delphine Rapoud (2) , Alexandre dos Santos (2) , Patrick Gonzalez (2) , Christophe Desterke (3) , Gérard Pascal (2) , Nabila Elarouci (1) , Mira Ayadi (1) , René Adam (2) , Daniel Azoulay (2) , Castaing Denis (2) , Eric Vibert (2) , Daniel Cherqui (2) , Didier Samuel (2) , Antonio Sa Cuhna (2) , Agnès Marchio (4) , Pascal Pineau (4) , Catherine Guettier (2) , Aurélien de Reyniès (1) , Jamila Faivre (2)

1 Ligue Nationale Contre le Cancer - Paris
2 Physiopathologie et traitement des maladies du foie
3 Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre
4 Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis

Intrahepatic cholangiocarcinoma (ICC) is asevere malignant tumor in which the standard therapies are mostly ineffective. The biological significance of the desmoplastic tumor microenvironment (TME) of ICC has been stressed, but was insufficiently taken into account in the search for classifications of ICC adapted to clinical trial design. We investigated the heterogeneous tumor stroma composition and built a TME-based classification of ICC tumors, which detects potentially targetable ICC subtypes.

Mots clés: Cancer Immunology; Immune Stratification; Tumor heterogeneity; Tumor infiltrating leukocytes (TILs); Tumor microenvironment

Domaines: Cancer

Sylvie Job, Delphine Rapoud, Alexandre dos Santos, Patrick Gonzalez, Christophe Desterke, et al.. Identification of four immune subtypes characterized by distinct composition and functions of tumor microenvironment in intrahepatic cholangiocarcinoma. Hepatology, 2019, ⟨10.1002/hep.31092⟩. ⟨pasteur-02611911⟩