Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy

Pierre Bruhns (1) , Jean-Luc Teillaud (2)

1 Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology
2 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers

In this issue of Cancer Cell, Dahan and colleagues demonstrate that modified Fc regions of agonistic anti-human CD40 mAbs can drastically increase their efficiency in a mouse pre-clinical model expressing human CD40 and IgG receptors. This study also highlights the fine balance between increased treatment efficacy and secondary side effects.

Domains: Immunology

Pierre Bruhns, Jean-Luc Teillaud. Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy. Cancer Cell, 2016, 29 (6), pp.771-773. ⟨10.1016/j.ccell.2016.05.009⟩. ⟨pasteur-02578652⟩