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Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy

Abstract : In this issue of Cancer Cell, Dahan and colleagues demonstrate that modified Fc regions of agonistic anti-human CD40 mAbs can drastically increase their efficiency in a mouse pre-clinical model expressing human CD40 and IgG receptors. This study also highlights the fine balance between increased treatment efficacy and secondary side effects.
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Submitted on : Thursday, May 14, 2020 - 7:02:01 PM
Last modification on : Friday, September 18, 2020 - 2:35:08 PM

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Pierre Bruhns, Jean-Luc Teillaud. Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy. Cancer Cell, Elsevier, 2016, 29 (6), pp.771-773. ⟨10.1016/j.ccell.2016.05.009⟩. ⟨pasteur-02578652⟩

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