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The function of Fcγ receptors in dendritic cells and macrophages

Martin Guilliams 1, 2 Pierre Bruhns 3 Yvan Saeys 1, 2 Hamida Hammad 1, 2 Bart Lambrecht 4, 1, 2
1 IRC - VIB-UGent Center for Inflammation Research [Gand, Belgique]
2 UGENT - Ghent University [Belgium]
3 Anticorps en Thérapie et Pathologie
4 Department of Pulmonary Medicine
Abstract : Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens and to receive feedback control from adaptive immune cells. Although it was long believed that all immunoglobulin Fc receptors are universally expressed by phagocytes, recent findings indicate that only monocyte-derived DCs and macrophages express high levels of activating Fc receptors for IgG (FcγRs), whereas conventional and plasmacytoid DCs express the inhibitory FcγR. In this Review, we discuss how the uptake, processing and presentation of antigens by DCs and macrophages is influenced by FcγR recognition of immunoglobulins and immune complexes in the steady state and during inflammation.
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Submitted on : Thursday, May 14, 2020 - 6:52:48 PM
Last modification on : Friday, May 15, 2020 - 2:12:40 AM

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Martin Guilliams, Pierre Bruhns, Yvan Saeys, Hamida Hammad, Bart Lambrecht. The function of Fcγ receptors in dendritic cells and macrophages. Nature Reviews Immunology, Nature Publishing Group, 2014, 14 (2), pp.94-108. ⟨10.1038/nri3582⟩. ⟨pasteur-02578340⟩

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