A. Agresti, Categorical Data Analysis, 3 rd edn, 2012.

N. L. Anderson and N. G. Anderson, The human plasma proteome: history, character, and diagnostic prospects, Mol Cell Proteomics, vol.1, pp.845-867, 2002.

H. Balci, H. Genc, C. Papila, G. Can, B. Papila et al., Serum lipid hydroperoxide levels and paraoxonase activity in patients with lung, breast, and colorectal cancer, J Clin Lab Anal, vol.26, pp.155-160, 2012.

Y. Benjamini and Y. Hochberg, Controlling the false discovery rate -a practical and powerful approach to multiple testing, J Roy Stat Soc B Met, vol.57, pp.289-300, 1995.

T. Bock, D. Bausch-fluck, A. Hofmann, and B. Wollscheid, CD proteome and beyond -technologies for targeting the immune cell surfaceome, Front Biosci, vol.17, pp.1599-1612, 2012.

J. G. Bode, U. Albrecht, D. Haussinger, P. C. Heinrich, and F. Schaper, Hepatic acute phase proteins-regulation by IL-6-and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kappaB-dependent signaling, Eur J Cell Biol, vol.91, pp.496-505, 2012.

R. A. Booth, Minimally invasive biomarkers for detection and staging of colorectal cancer, Cancer Lett, vol.249, pp.87-96, 2007.

H. Brenner, J. Chang-claude, C. M. Seiler, T. Sturmer, and M. Hoffmeister, Does a negative screening colonoscopy ever need to be repeated?, Gut, vol.55, pp.1145-1150, 2006.

H. Brenner, J. Chang-claude, C. M. Seiler, T. Sturmer, and M. Hoffmeister, Case-control study supports extension of surveillance interval after colonoscopic polypectomy to at least 5 year, Am J Gastroenterol, vol.102, pp.1739-1744, 2007.

H. Brenner, U. Haug, and S. Hundt, Inter-test agreement and quantitative cross-validation of immunochromatographical fecal occult blood tests, Int J Cancer, vol.127, pp.1643-1649, 2010.

M. Bretthauer, Colorectal cancer screening, J Intern Med, vol.270, pp.87-98, 2011.

L. Bujanda, C. Sarasqueta, A. Cosme, E. Hijona, J. M. Enriquez-navascues et al., Evaluation of alpha 1-antitrypsin and the levels of mRNA expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and COX-2 for the diagnosis of colorectal cancer, PLoS ONE, vol.8, p.51810, 2013.

N. Bulbuller, E. Eren, H. Y. Ellidag, O. Z. Oner, C. Sezer et al., Diagnostic value of thiols, paraoxonase 1, arylesterase and oxidative balance in colorectal cancer in human, Neoplasma, vol.60, pp.419-424, 2013.

, Comprehensive molecular characterization of human colon and rectal cancer, Cancer Genome Atlas N, vol.487, pp.330-337, 2012.

S. A. Carr, S. E. Abbatiello, B. L. Ackermann, C. Borchers, B. Domon et al., Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach, 2014.

, Mol Cell Proteomics, vol.13, pp.907-917

M. Choi, C. Y. Chang, T. Clough, D. Broudy, T. Killeen et al., MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments, Bioinformatics, vol.30, pp.2524-2526, 2014.

W. S. Cleveland, E. Grosse, and M. J. Shyu, Local Regression Models, pp.309-376, 1992.

B. Efron and R. Tibshirani, An Introduction to the Bootstrap, 1993.

T. Farrah, E. W. Deutsch, R. Kreisberg, Z. Sun, D. S. Campbell et al., PASSEL: the peptideAtlas SRMexperiment library, Proteomics, vol.12, pp.1170-1175, 2012.

B. B. Haab, B. H. Geierstanger, G. Michailidis, F. Vitzthum, S. Forrester et al., Immunoassay and antibody microarray analysis of the HUPO Plasma Proteome Project reference specimens: systematic variation between sample types and calibration of mass spectrometry data, Proteomics, vol.5, pp.3278-3291, 2005.

E. Hadler-olsen, J. O. Winberg, and L. Uhlin-hansen, Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets, Tumour Biol, vol.34, pp.2041-2051, 2013.

D. Hanahan and R. A. Weinberg, Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011.

M. N. Holten-andersen, I. J. Christensen, H. J. Nielsen, R. W. Stephens, V. Jensen et al., Total levels of tissue inhibitor of metalloproteinases 1 in plasma yield high diagnostic sensitivity and specificity in patients with colon cancer, Clin Cancer Res, vol.8, pp.156-164, 2002.

G. L. Hortin, D. Sviridov, and N. L. Anderson, High-abundance polypeptides of the human plasma proteome comprising the top 4 logs of polypeptide abundance, Clin Chem, vol.54, pp.1608-1616, 2008.

S. Hundt, U. Haug, and H. Brenner, Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection, Ann Intern Med, vol.150, pp.162-169, 2009.

A. Kapidzic, E. J. Grobbee, L. Hol, A. H. Van-roon, A. J. Van-vuuren et al., Attendance and yield over three rounds of population-based fecal immunochemical test screening, Am J Gastroenterol, vol.109, pp.1257-1264, 2014.

A. Keller, A. I. Nesvizhskii, E. Kolker, and R. Aebersold, Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search, Anal Chem, vol.74, pp.5383-5392, 2002.

J. J. Ladd, T. Busald, M. M. Johnson, Q. Zhang, S. J. Pitteri et al., Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women, Cancer Prev Res, vol.5, pp.655-664, 2012.

G. Li, R. Fridman, and H. R. Kim, Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells, Cancer Res, vol.59, pp.6267-6275, 1999.

G. Y. Locker, S. Hamilton, J. Harris, J. M. Jessup, N. Kemeny et al., ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer, J Clin Oncol, vol.24, pp.5313-5327, 2006.

B. Maclean, D. M. Tomazela, N. Shulman, M. Chambers, G. L. Finney et al., Skyline: an open source document editor for creating and analyzing targeted proteomics experiments, Bioinformatics, vol.26, pp.966-968, 2010.

A. I. Nesvizhskii, A. Keller, E. Kolker, and R. Aebersold, A statistical model for identifying proteins by tandem mass spectrometry, Anal Chem, vol.75, pp.4646-4658, 2003.

M. Polanski and N. L. Anderson, A list of candidate cancer biomarkers for targeted proteomics, Biomark Insights, vol.1, pp.1-48, 2007.

J. Roth, Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions, Chem Rev, vol.102, pp.285-303, 2002.

R. Schiess, B. Wollscheid, and R. Aebersold, Targeted proteomic strategy for clinical biomarker discovery, Mol Oncol, vol.3, pp.33-44, 2009.

G. K. Smyth and T. Speed, Normalization of cDNA microarray data, Methods, vol.31, pp.265-273, 2003.

L. H. Sobin, TNM: evolution and relation to other prognostic factors, Semin Surg Oncol, vol.21, pp.3-7, 2003.

M. Sturm, A. Bertsch, C. Gropl, A. Hildebrandt, R. Hussong et al., OpenMS -an open-source software framework for mass spectrometry, BMC Bioinformatics, vol.9, p.163, 2008.

S. Surinova, L. Radová, M. Choi, J. Srovnal, H. Brenner et al., Non-invasive prognostic protein biomarker signatures associated with colorectal cancer, EMBO Mol Med, vol.7, pp.1153-1165, 2015.

S. Tao, U. Haug, K. Kuhn, and H. Brenner, Comparison and combination of blood-based inflammatory markers with faecal occult blood tests for noninvasive colorectal cancer screening, Br J Cancer, vol.106, pp.1424-1430, 2012.

C. Walker and B. N. Gray, Acute-phase reactant proteins and carcinoembryonic antigen in cancer of the colon and rectum, Cancer, vol.52, pp.150-154, 1983.

X. Wang, S. Abraham, J. A. Mckenzie, N. Jeffs, M. Swire et al., LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling, Nature, vol.499, pp.306-311, 2013.

H. Weisser, S. Nahnsen, J. Grossmann, L. Nilse, A. Quandt et al., An automated pipeline for high-throughput label-free quantitative proteomics, J Proteome Res, vol.12, pp.1628-1644, 2013.

H. Zhang, X. J. Li, D. B. Martin, and R. Aebersold, Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry, Nat Biotechnol, vol.21, pp.660-666, 2003.

H. Zhang, A. Y. Liu, P. Loriaux, B. Wollscheid, Y. Zhou et al., Mass spectrometric detection of tissue proteins in plasma, Mol Cell Proteomics, vol.6, pp.64-71, 2007.

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