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Human Plasmodium vivax diversity, population structure and evolutionary origin

Virginie Rougeron 1, * Eric Elguero 1 Céline Arnathau 1 Beatriz Acuña Hidalgo 1 Patrick Durand 1 Sandrine Houzé 2 Antoine Berry 3, 4 Sedigheh Zakeri 5 Rashidul Haque 6 Mohammad Shafiul Alam 6 François Nosten 7, 8 Carlo Severini 9 Tamirat Gebru Woldearegai 10, 11, 12 Benjamin Mordmüller 10, 11 Peter Gottfried Kremsner 10 Lilia González-Cerón 13 Gustavo Fontecha 14 Dionicia Gamboa 15 Lise Musset 16 Eric Legrand 17 Oscar Noya 18, 19 Tepanata Pumpaibool 20, 21 Pingchai Harnyuttanakorn 21, 22 Khadijetou Mint Lekweiry 23 Musab Mohamad Albsheer 24 Muzamil Mahdi Abdel Hamid 24 Ali Ould Mohamed Salem Boukary 23, 25 Jean-Francois Trape 1 Francois Renaud 1 Franck Prugnolle 1
* Corresponding author
Abstract : More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in comparison with Plasmodium falciparum. A renewed interest has emerged in the past decade with the discovery of antimalarial drug resistance and of severe and even fatal human cases. Nonetheless, today there are still significant gaps in our understanding of the population genetics and evolutionary history of P. vivax, particularly because of a lack of genetic data from Africa. To address these gaps, we genotyped 14 microsatellite loci in 834 samples obtained from 28 locations in 20 countries from around the world. We discuss the worldwide population genetic structure and diversity and the evolutionary origin of P. vivax in the world and its introduction into the Americas. This study demonstrates the importance of conducting genome-wide analyses of P. vivax in order to unravel its complex evolutionary history.
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Virginie Rougeron, Eric Elguero, Céline Arnathau, Beatriz Acuña Hidalgo, Patrick Durand, et al.. Human Plasmodium vivax diversity, population structure and evolutionary origin. PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (3), pp.e0008072. ⟨10.1371/journal.pntd.0008072⟩. ⟨pasteur-02567249⟩

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