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SME-4-producing Serratia marcescens from Argentina belonging to clade 2 of the S. marcescens phylogeny

Abstract : Background: SME carbapenemases are increasingly reported, especially from North and South America. Here, we describe an SME-4-producing Serratia marcescens (SME-Sm) clinical isolate from Argentina and compare its genome with other SME-Sm and Sm isolates recovered from public databases. Methods: Sm isolates were characterized by WGS using Illumina technology, susceptibility testing and MIC determination. Carbapenemase activity was revealed by biochemical tests based on imipenem hydrolysis. A whole-genome phylogeny was estimated for all the Sm isolates retrieved from public databases with kSNP3 and a whole-genome phylogenetic analysis based on non-recombinant core SNPs was inferred for Sm complete genomes and for those encoding any bla SME variants.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02565488
Contributor : Philippe Glaser <>
Submitted on : Wednesday, May 6, 2020 - 2:52:16 PM
Last modification on : Thursday, October 15, 2020 - 4:06:15 AM

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Laura Dabos, Rafael Patino-Navarrete, Marcela Nastro, Angela Famiglietti, Philippe Glaser, et al.. SME-4-producing Serratia marcescens from Argentina belonging to clade 2 of the S. marcescens phylogeny. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2019, 74 (7), pp.1836-1841. ⟨10.1093/jac/dkz115⟩. ⟨pasteur-02565488⟩

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