 |
Journal articles
Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae
Abstract : Background: In fast-growing bacteria, the genomic location of ribosomal protein (RP) genes is biased towards the replication origin (oriC). This trait allows optimizing their expression during exponential phase since oriC neighboring regions are in higher dose due to multifork replication. Relocation of s10-spc-α locus (S10), which codes for most of the RP, to ectopic genomic positions shows that its relative distance to the oriC correlates to a reduction on its dosage, its expression, and bacterial growth rate. However, a mechanism linking S10 dosage to cell physiology has still not been determined.
Cited literature [84 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02562489
Contributor : Hugo Varet Connect in order to contact the contributor
Submitted on : Monday, May 4, 2020 - 5:03:15 PM
Last modification on : Monday, November 22, 2021 - 4:14:05 PM
Contributor : Hugo Varet Connect in order to contact the contributor
Submitted on : Monday, May 4, 2020 - 5:03:15 PM
Last modification on : Monday, November 22, 2021 - 4:14:05 PM
File
s12915-020-00777-5.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License