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Article Dans Une Revue BMC Genomics Année : 2018

Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation

Odile Sismeiro
Bernd Jagla
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Marie-Agnès Dillies
Hugo Varet
Jean-Yves Coppée

Résumé

The SOS response is an almost ubiquitous response of cells to genotoxic stresses. The full complement of genes in the SOS regulon for Vibrio species has only been addressed through bioinformatic analyses predicting LexA binding box consensus and in vitro validation. Here, we perform whole transcriptome sequencing from Vibrio cholerae treated with mitomycin C as an SOS inducer to characterize the SOS regulon and other pathways affected by this treatment.
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pasteur-02562431 , version 1 (04-05-2020)

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Evelyne Krin, Sebastian Aguilar Pierlé, Odile Sismeiro, Bernd Jagla, Marie-Agnès Dillies, et al.. Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation. BMC Genomics, 2018, 19 (1), pp.373. ⟨10.1186/s12864-018-4716-8⟩. ⟨pasteur-02562431⟩
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