Immune parameters and outcomes during Ebola virus disease

Stéphanie Reynard (1) , Alexandra Journeaux (1) , Emilie Gloaguen (2) , Justine Schaeffer (1) , Hugo Varet (3) , Natalia Pietrosemoli (3) , Mathieu Mateo (1) , Nicolas Baillet (1) , Cédric Laouénan (4, 2) , Hervé Raoul (5) , Jimmy Mullaert (2) , Sylvain Baize (1)

1 UBIVE - Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections
2 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
3 Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB
4 Département d'épidémiologie, biostatistique et recherche clinique
5 Laboratoire P4 - Jean Mérieux

The West African Ebola virus epidemic from 2014-2016 highlighted the lack of knowledge about the pathogenicity of the virus and the factors responsible for outcome. A performant and rapid diagnosis is of crucial importance, as is overcoming the difficulty of providing high-quality patient management during such an extensive outbreak. Here, we propose to study the role of the immune mediators during Ebola virus disease and to define some molecules of importance in the outcome.

Keywords: Virology; Chemokines; Cytokines; Infectious disease; Innate immunity

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Life Sciences [q-bio]; Immunology

Stéphanie Reynard, Alexandra Journeaux, Emilie Gloaguen, Justine Schaeffer, Hugo Varet, et al.. Immune parameters and outcomes during Ebola virus disease. JCI Insight, 2019, 4 (1), ⟨10.1172/jci.insight.125106⟩. ⟨pasteur-02562418⟩