Skip to Main content Skip to Navigation
Journal articles

Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire

Abstract : All cellular life forms are afflicted by diverse genetic parasites, including viruses and other types of mobile genetic elements (MGEs), and have evolved multiple, diverse defence systems that protect them from MGE assault via different mechanisms. Here, we provide our perspectives on how recent evidence points to tight evolutionary connections between MGEs and defence systems that reach far beyond the proverbial arms race. Defence systems incur a fitness cost for the hosts; therefore, at least in prokaryotes, horizontal mobility of defence systems, mediated primarily by MGEs, is essential for their persistence. Moreover, defence systems themselves possess certain features of selfish elements. Common components of MGEs, such as site-specific nucleases, are 'guns for hire' that can also function as parts of defence mechanisms and are often shuttled between MGEs and defence systems. Thus, evolutionary and molecular factors converge to mould the multifaceted, inextricable connection between MGEs and anti-MGE defence systems.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-02559898
Contributor : Mart Krupovic <>
Submitted on : Thursday, April 30, 2020 - 6:43:31 PM
Last modification on : Monday, May 4, 2020 - 2:40:23 PM

Identifiers

Collections

Citation

Eugene V Koonin, Kira S Makarova, Yuri I Wolf, Mart Krupovic. Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire. Nature Reviews Genetics, Nature Publishing Group, 2020, 21 (2), pp.119-131. ⟨10.1038/s41576-019-0172-9⟩. ⟨pasteur-02559898⟩

Share

Metrics

Record views

51