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Publisher Correction: Definitions and guidelines for research on antibiotic persistence

Nathalie Balaban 1, * Sophie Helaine 2 Kim Lewis 3 Martin Ackermann 4, 5 Bree Aldridge 6 Dan Andersson 7 Mark Brynildsen 8 Dirk Bumann 9 Andrew Camilli 6 James Collins 10, 11, 12 Christoph Dehio 9 Sarah Fortune 13 Jean-Marc Ghigo 14 Wolf-Dietrich Hardt 15, 16 Alexander Harms 9 Matthias Heinemann 17 Deborah Hung 12 Urs Jenal 9 Bruce Levin 18 Jan Michiels 19 Gisela Storz 20 Man-Wah Tan 21 Tanel Tenson 22 Laurence van Melderen 23 Annelies Zinkernagel 24
Abstract : Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.
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Nathalie Balaban, Sophie Helaine, Kim Lewis, Martin Ackermann, Bree Aldridge, et al.. Publisher Correction: Definitions and guidelines for research on antibiotic persistence. Nature Reviews Microbiology, Nature Publishing Group, 2019, 17 (7), pp.441-448. ⟨10.1038/s41579-019-0196-3⟩. ⟨pasteur-02558489⟩

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