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Journal articles
Structural Insights Into the Catalytic Mechanism of Trypanosoma Cruzi Trans-Sialidase
Abstract : Sialidases are a superfamily of sialic-acid-releasing enzymes that are of significant interest due to their implication as virulence factors in the pathogenesis of a number of diseases. However, extensive studies of viral and microbial sialidases have failed to provide a comprehensive picture of their mechanistic properties, in part because the structures of competent enzyme-substrate complexes and reaction intermediates have never been described. Here we report these structures for the Trypanosoma cruzi trans-sialidase (TcTS), showing that catalysis by sialidases occurs via a similar mechanism to that of other retaining glycosidases, but with some intriguing differences that may have evolved in response to the substrate structure.
Cited literature [15 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-02554101
Contributor : Alejandro Buschiazzo <>
Submitted on : Friday, April 24, 2020 - 11:53:43 PM
Last modification on : Friday, March 19, 2021 - 6:10:02 PM
Contributor : Alejandro Buschiazzo <>
Submitted on : Friday, April 24, 2020 - 11:53:43 PM
Last modification on : Friday, March 19, 2021 - 6:10:02 PM