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Structural Insights Into the Catalytic Mechanism of Trypanosoma Cruzi Trans-Sialidase

Abstract : Sialidases are a superfamily of sialic-acid-releasing enzymes that are of significant interest due to their implication as virulence factors in the pathogenesis of a number of diseases. However, extensive studies of viral and microbial sialidases have failed to provide a comprehensive picture of their mechanistic properties, in part because the structures of competent enzyme-substrate complexes and reaction intermediates have never been described. Here we report these structures for the Trypanosoma cruzi trans-sialidase (TcTS), showing that catalysis by sialidases occurs via a similar mechanism to that of other retaining glycosidases, but with some intriguing differences that may have evolved in response to the substrate structure.
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Contributor : Alejandro Buschiazzo Connect in order to contact the contributor
Submitted on : Friday, April 24, 2020 - 11:53:43 PM
Last modification on : Thursday, April 7, 2022 - 10:10:27 AM

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María Fernanda Amaya, Andrew G Watts, Iben Damager, Annemarie Wehenkel, Tong Nguyen, et al.. Structural Insights Into the Catalytic Mechanism of Trypanosoma Cruzi Trans-Sialidase. Structure, 2004, 12 (5), pp.775 - 784. ⟨10.1016/j.str.2004.02.036⟩. ⟨pasteur-02554101⟩



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