Stationary phase and mature infectious forms of Legionella pneumophila produce distinct viable but non-culturable cells, Environ. Microbiol, vol.16, pp.382-395, 2014. ,
Legionella pneumophila -a human pathogen that co-evolved with fresh water protozoa, Cell Mol. Life Sci, vol.64, pp.432-448, 2007. ,
Control of flagellar gene regulation in Legionella pneumophila and its relation to growth phase, J. Bacteriol, vol.192, pp.446-455, 2010. ,
The PmrA/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoa, Infect. Immun, vol.77, pp.374-386, 2009. ,
The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates, J. Bacteriol, vol.90, 1985. ,
The flagellar regulon of Legionella-a review, Front. Cell. Infect. Microbiol, vol.7, p.454, 2017. ,
Genetic evidence that Legionella pneumophila RpoS modulates expression of the transmission phenotype in both the exponential phase and the stationary phase, Infect. Immun, vol.72, pp.2468-2476, 2004. ,
Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila, Antimicrob. Agents Chemother, vol.39, pp.2684-2688, 1995. ,
Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile, J. Bacteriol, vol.196, pp.3234-3248, 2014. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02440841
Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome-lysosome fusion, Infect. Immun, vol.64, pp.668-673, 1996. ,
The role of Legionella pneumophila-infected Hartmannella vermiformis as an infectious particle in a murine model of Legionnaire's disease, Infect. Immun, vol.65, pp.5330-5333, 1997. ,
Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila, Cell. Microbiol, vol.8, pp.1228-1240, 2006. ,
Expression of Legionella pneumophila virulence traits in response to growth conditions, Infect. Immun, vol.66, pp.3029-3034, 1998. ,
Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease, PLoS Genet, vol.6, p.1000851, 2010. ,
Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity, Nat. Genet, vol.36, pp.1165-1173, 2004. ,
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation, Science, vol.338, pp.1072-1076, 2012. ,
Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion, Infect. Immun, vol.62, pp.3254-3261, 1994. ,
Probable person-to-person transmission of Legionnaires' disease, N. Engl. J. Med, vol.374, pp.497-498, 2016. ,
Legionnaires' disease, Lancet, vol.387, pp.376-385, 2016. ,
SpoT governs Legionella pneumophila differentiation in host macrophages, Mol. Microbiol, vol.71, pp.640-658, 2009. ,
, ppGpp conjures bacterial virulence. Microbiol. Mol. Biol. Rev, vol.74, pp.171-199, 2010.
ppGpp: magic beyond RNA polymerase, Nat. Rev. Microbiol, vol.10, pp.203-212, 2012. ,
Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer, Mol. Microbiol, vol.76, pp.7716-7726, 2005. ,
Positive and negative regulation of the master metabolic regulator mTORC1 by two families of Legionella pneumophila effectors, Cell Rep, vol.21, pp.2031-2038, 2017. ,
Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells, Infect. Immun, vol.69, pp.2116-2122, 2001. ,
The multi-step design of the LetA/LetS two-component system increases Legionella pneumophila versatility, Infect. Immun, vol.78, pp.2571-2583, 2010. ,
The life stage-specific pathometabolism of Legionella pneumophila, FEBS Lett, vol.590, pp.3868-3886, 2016. ,
Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy, Nat. Rev. Microbiol, vol.14, pp.5-19, 2016. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01326394
From amoeba to macrophages: exploring the molecular mechanisms of Legionella pneumophila infection in both hosts, Curr. Top. Microbiol. Immunol, vol.376, pp.1-34, 2013. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01334244
Isotopologue profiling of Legionella pneumophila: role of serine and glucose as carbon substrates, J. Biol. Chem, vol.285, pp.22232-22243, 2010. ,
Legionella pneumophila transcriptome during intracellular multiplication in human macrophages, Front. Microbiol, vol.2, p.60, 2011. ,
Ultrastructural analysis of differentiation in Legionella pneumophila, J. Bacteriol, vol.184, pp.7025-7041, 2002. ,
The molecular ecology of Legionellae, Trends Microbiol, vol.4, pp.286-290, 1996. ,
Legionella and Legionnaires' disease: 25 years of investigation, Clin. Microbiol. Rev, vol.15, pp.506-526, 2002. ,
Identification of CpxR as a positive regulator of icm and dot virulence genes of Legionella pneumophila, J. Bacteriol, vol.185, pp.4908-4919, 2003. ,
The Legionella pneumophila GacA homolog (LetA) is involved in the regulation of icm virulence genes and is required for intracellular multiplication in Acanthamoeba castellanii, Microb. Pathog, vol.34, pp.187-194, 2003. ,
Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms, Infect. Immun, vol.70, pp.6273-6283, 2002. ,
Amino acid requirements of Legionella pneumophila, J. Clin. Microbiol, vol.11, pp.286-291, 1980. ,
Growth-related metabolism of the carbon storage Poly-3-hydroxybutyrate in Legionella pneumophila, J. Biol. Chem, vol.291, pp.6471-6482, 2016. ,
Comparative and functional genomics of Legionella identified eukaryotic like proteins as key players in host-pathogen interactions, Front. Microbiol, vol.2, p.208, 2011. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01422820
The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii, J. Bacteriol, vol.181, pp.4879-4889, 1999. ,
A twocomponent regulator induces the transmission phenotype of stationary-phase Legionella pneumophila, Mol. Microbiol, vol.33, pp.107-118, 1999. ,
Glucose metabolism in Legionella pneumophila: dependence on the Entner-Doudoroff pathway and connection with intracellular bacterial growth, J. Bacteriol, vol.192, pp.2892-2899, 2010. ,
Advances in bacterial promoter recognition and its control by factors that do not bind DNA, Nat. Rev. Microbiol, vol.6, pp.507-519, 2008. ,
Pathway analysis using (13) C-glycerol and other carbon tracers reveals a bipartite metabolism of Legionella pneumophila, Mol. Microbiol, vol.100, pp.229-246, 2016. ,
Legionella pneumophila CsrA regulates a metabolic switch from amino acid to glycerolipid metabolism, Open Biol, vol.7, p.170149, 2017. ,
GamA is a eukaryotic-like glucoamylase responsible for glycogen-and starch-degrading activity of Legionella pneumophila, Int. J. Med. Microbiol, vol.301, pp.133-139, 2011. ,
Influence of the alternative sigma(28) factor on virulence and flagellum expression of Legionella pneumophila, Infect. Immun, vol.70, pp.1604-1608, 2002. ,
The alternative sigma factor sigma28 of Legionella pneumophila restores flagellation and motility to an Escherichia coli fliA mutant, J. Bacteriol, vol.179, pp.17-23, 1997. ,
The flagellum of Legionella pneumophila and its link to the expression of the virulent phenotype, Int. J. Med. Microbiol, vol.293, pp.133-143, 2003. ,
Legionella spp. outdoors: colonization, communication and persistence, Environ. Microbiol. Rep, vol.3, pp.286-296, 2011. ,
Update on Legionnaires' disease: pathogenesis, epidemiology, detection and control, Mol. Microbiol, vol.76, pp.1-11, 2010. ,
Environmental predators as models for bacterial pathogenesis, Environ. Microbiol, vol.9, pp.563-575, 2007. ,
Intra-species and inter-kingdom signaling of Legionella pneumophila, Front. Microbiol, vol.8, p.79, 2017. ,
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes, J. Clin. Invest, vol.66, pp.441-450, 1980. ,
SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila, J. Bacteriol, vol.191, pp.2461-2473, 2009. ,
MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth, Proc. Natl. Acad. Sci. U.S.A, vol.112, pp.5208-5217, 2015. ,
The Legionella pneumophila replication vacuole: making a cosy niche inside host cells, Nat. Rev. Microbiol, vol.7, pp.13-24, 2009. ,
Characterization of the alternative sigma factor sigma54 and the transcriptional regulator FleQ of Legionella pneumophila, which are both involved in the regulation cascade of flagellar gene expression, J. Bacteriol, vol.186, pp.2540-2547, 2004. ,
Poly-3-hydroxybutyrate in Legionella pneumophila, an energy source for survival in low-nutrient environments, Appl. Environ. Microbiol, vol.65, pp.822-827, 1999. ,
Regulation of sigma factor competition by the alarmone ppGpp, Genes Dev, vol.16, pp.1260-1270, 2002. ,
Prediction of CsrA-regulating small RNAs in bacteria and their experimental verification in Vibrio fischeri, Nucleic Acids Res, vol.34, pp.3361-3369, 2006. ,
Characterisation of Legionella pneumophila phospholipases and their impact on host cells, Eur. J. Cell Biol, vol.90, pp.903-912, 2011. ,
The RNA molecule CsrB binds to the global regulatory protein CsrA and antagonizes its activity in Escherichia coli, J. Biol. Chem, vol.272, pp.17502-17510, 1997. ,
The response regulator LetA regulates the stationary-phase stress response in Legionella pneumophila and is required for efficient infection of Acanthamoeba castellanii, FEMS Microbiol. Lett, vol.12, pp.241-248, 2003. ,
Metabolism of myo-inositol by Legionella pneumophila promotes infection of amoeba and macrophages, Appl. Environ. Microbiol, vol.82, pp.5000-5014, 2016. ,
Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease, N. Engl. J. Med, vol.297, pp.1197-1203, 1977. ,
The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA, J. Bacteriol, vol.187, pp.1527-1532, 2005. ,
Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication, Mol. Microbiol, vol.50, pp.445-461, 2003. ,
Differentiate to thrive: lessons from the Legionella pneumophila life cycle, Mol. Microbiol, vol.53, pp.29-40, 2004. ,
Molecular pathogenesis of infections caused by Legionella pneumophila, Clin. Microbiol. Rev, vol.23, pp.274-298, 2010. ,
Effector proteins translocated by Legionella pneumophila: strength in numbers, Trends Microbiol, vol.15, pp.372-380, 2007. ,
Molecular mimicry: an important virulence strategy employed by Legionella pneumophila to subvert host functions, Future Microbiol, vol.4, pp.691-701, 2009. ,
A unique cis-encoded small noncoding RNA is regulating Legionella pneumophila Hfq expression in a life cycle-dependent manner, MBio, vol.8, pp.2182-2198, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01687067
General aspects of two-component regulatory circuits in bacteria: domains, signals and roles, Curr. Protein Pept. Sci, vol.18, pp.990-1004, 2017. ,
Development of a chemically defined liquid medium for growth of Legionella pneumophila, J. Clin. Microbiol, vol.9, pp.615-626, 1979. ,
(p)ppGpp: still magical?, Annu. Rev. Microbiol, vol.62, pp.35-51, 2008. ,
Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa, PLoS Pathog, vol.5, p.1000704, 2009. ,
Host proteasomal degradation generates amino acids essential for intracellular bacterial growth, Science, vol.334, pp.1553-1557, 2011. ,
The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors, Mol. Microbiol, vol.72, pp.995-1010, 2009. ,
Chemically defined medium for Legionella pneumophila growth, J. Clin. Microbiol, vol.13, pp.115-119, 1981. ,
The many forms of a pleomorphic bacterial pathogen-the developmental network of Legionella pneumophila, Front. Microbiol, vol.5, p.670, 2014. ,
Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophila, Cell. Microbiol, vol.8, pp.793-805, 2006. ,
Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy, Proc. Natl. Acad. Sci. U.S.A, vol.113, pp.1901-1906, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01376135
Current views on the relationships between amoebae, legionellae and man, Isr. J. Med. Sci, vol.22, pp.678-689, 1986. ,
Two small ncRNAs jointly govern virulence and transmission in Legionella pneumophila, Mol. Microbiol, vol.72, pp.741-762, 2009. ,
Deep sequencing defines the transcriptional map of L. pneumophila and identifies growth phase-dependent regulated ncRNAs implicated in virulence, RNA Biol, vol.9, pp.503-519, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01338351
The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system, PLoS Genet, vol.13, p.1006629, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01570214
The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages, Proc. Natl. Acad. Sci. U.S.A, vol.102, pp.9924-9929, 2005. ,
Amino acid uptake and metabolism of Legionella pneumophila hosted by Acanthamoeba castellanii, J. Biol. Chem, vol.289, pp.21040-21054, 2014. ,
Resuscitation of viable but nonculturable Legionella pneumophila Philadelphia JR32 by Acanthamoeba castellanii, Appl. Environ. Microbiol, vol.63, pp.2047-2053, 1997. ,
Legionella pneumophila: an aquatic microbe goes astray, FEMS Microbiol. Rev, vol.26, pp.149-162, 2002. ,
Legionella pathogenicity: genome structure, regulatory networks and the host cell response, Int. J. Med. Microbiol, vol.297, pp.577-587, 2007. ,
Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles, J. Exp. Med, vol.192, pp.1261-1272, 2000. ,
Intermediary metabolism in Legionella pneumophila: utilization of amino acids and other compounds as energy sources, J. Bacteriol, vol.154, pp.1104-1109, 1983. ,
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA, Cell. Microbiol, vol.9, pp.2903-2920, 2007. ,
A regulatory feedback loop between RpoS and SpoT supports the survival of Legionella pneumophila in water, Appl. Environ. Microbiol, vol.81, pp.918-928, 2015. ,
Analysis of the transcriptome of Legionella pneumophila hfq mutant reveals a new mobile genetic element, Microbiology, vol.159, pp.1649-1660, 2013. ,
Glucose and glutamate metabolism of Legionella pneumophila, Curr. Microbiol, vol.4, pp.1-6, 1980. ,
Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5, Mol. Microbiol, vol.55, pp.1528-1537, 2005. ,
Residual guanosine 3' ,5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations, J. Biol. Chem, vol.266, pp.5980-5990, 1991. ,
Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative survey, J. Infect. Dis, vol.186, pp.127-128, 2002. ,
Comprehensive identification of protein substrates of the Dot/Icm type iv transporter of Legionella pneumophila, PLoS ONE, vol.6, p.17638, 2011. ,
The response regulator PmrA is a major regulator of the icm/dot type IV secretion system in Legionella pneumophila and Coxiella burnetii, Mol. Microbiol, vol.63, pp.1508-1523, 2007. ,
Characterization of a Legionella pneumophila relA insertion mutant and toles of RelA and RpoS in virulence gene expression, J. Bacteriol, vol.184, pp.67-75, 2002. ,