Skip to Main content Skip to Navigation
Journal articles

The Life Cycle of L. pneumophila: Cellular Differentiation Is Linked to Virulence and Metabolism

Abstract : Legionella pneumophila is a gram-negative bacterium that inhabits freshwater ecosystems, where it is present in biofilm or as planktonic form. L. pneumophila is mainly found associated with protozoa, which serve as protection from hostile environments and as replication niche. If inhaled within aerosols, L. pneumophila is also able to infect and replicate in human alveolar macrophages, eventually causing the Legionnaires' disease. The transition between intracellular and extracellular environments triggers a differentiation program in which metabolic as well as morphogenetic changes occur. We here describe the current knowledge on how the different developmental states of this bacterium are regulated, with a particular emphasis on the stringent response activated during the transition from the replicative phase to the infectious phase and the metabolic features going in hand. We propose that the cellular differentiation of this intracellular pathogen is closely associated to key metabolic changes in the bacterium and the host cell, which together have a crucial role in the regulation of L. pneumophila virulence.
Document type :
Journal articles
Complete list of metadatas

Cited literature [105 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02553277
Contributor : Isabelle Hoffmann <>
Submitted on : Friday, April 24, 2020 - 11:54:15 AM
Last modification on : Tuesday, October 20, 2020 - 9:50:06 AM

File

2018 Frontiers_Oliva.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Giulia Oliva, Tobias Sahr, Carmen Buchrieser. The Life Cycle of L. pneumophila: Cellular Differentiation Is Linked to Virulence and Metabolism. Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, Biology and Pathogenesis of Legionella, 8, pp.3. ⟨10.3389/fcimb.2018.00003⟩. ⟨pasteur-02553277⟩

Share

Metrics

Record views

51

Files downloads

88