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Journal Articles Journal of Infectious Diseases Year : 2018

Protection of the Human Gut Microbiome From Antibiotics

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Jean de Gunzburg
  • Function : relator_co_first_author
  • PersonId : 1068528
Amine Ghozlane
Annie Ducher
  • Function : relator_co_first_author
Emmanuelle Le Chatelier
Etienne Ruppé
  • Function : Author
  • PersonId : 1016938
Florence Levenez
  • Function : Author
  • PersonId : 1204140
Sean Kennedy
  • Function : Author
  • PersonId : 1203215
Nicolas Pons
  • Function : Author
  • PersonId : 1203780

Abstract

Background: Antibiotics are life-saving drugs but severely affect the gut microbiome with short-term consequences including diarrhea and selection of antibiotic-resistant bacteria. Long-term links to allergy and obesity are also suggested. We devised a product, DAV132, and previously showed its ability to deliver a powerful adsorbent, activated charcoal, in the late ileum of human volunteers. Methods: We performed a randomized controlled trial in 28 human volunteers treated with a 5-day clinical regimen of the fluoroquinolone antibiotic moxifloxacin in 2 parallel groups, with or without DAV132 coadministration. Two control goups of 8 volunteers each receiving DAV132 alone, or a nonactive substitute, were added. Results: The coadministration of DAV132 decreased free moxifloxacin fecal concentrations by 99%, while plasmatic levels were unaffected. Shotgun quantitative metagenomics showed that the richness and composition of the intestinal microbiota were largely preserved in subjects co-treated with DAV132 in addition to moxifloxacin. No adverse effect was observed. In addition, DAV132 efficiently adsorbed a wide range of clinically relevant antibiotics ex vivo. Conclusions: DAV132 was highly effective to protect the gut microbiome of moxifloxacin-treated healthy volunteers and may constitute a clinical breakthrough by preventing adverse health consequences of a wide range of antibiotic treatments. Clinical Trials Registration: NCT02176005.
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Dates and versions

pasteur-02552147 , version 1 (23-04-2020)

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Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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Jean de Gunzburg, Amine Ghozlane, Annie Ducher, Emmanuelle Le Chatelier, Xavier Marie Duval, et al.. Protection of the Human Gut Microbiome From Antibiotics. Journal of Infectious Diseases, 2018, 217 (4), pp.628-636. ⟨10.1093/infdis/jix604⟩. ⟨pasteur-02552147⟩
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