Legionella Effectors Explored with INSeq: New Functional Insights

Monica Rolando (1) , Carmen Buchrieser (1)

1 Biologie des Bactéries intracellulaires - Biology of Intracellular Bacteria

Legionella pneumophila secretes over 300 effector proteins that manipulate host cells. This multiplicity of effectors hampers the characterization of their individual roles. Shames et al. report a new approach to solve the enigma of Legionella effector function by using INSeq to analyse effector functions in the context of infection.

Keywords: virulence factors; Legionella pneumophila; bacterial effectors; transposon insertion sequencing

Domains: Life Sciences [q-bio]

Monica Rolando, Carmen Buchrieser. Legionella Effectors Explored with INSeq: New Functional Insights. Trends in Microbiology, 2018, 26 (3), pp.169-170. ⟨10.1016/j.tim.2018.01.003⟩. ⟨pasteur-02552011⟩