S. H. Wong, L. Zhao, X. Zhang, G. Nakatsu, J. Han et al., , p.685

W. K. Tsoi, B. Wu, F. K. Zeng, J. J. Chan, H. Sung et al., Gavage of Fecal 686

, Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-687

C. Free and . Mice, Gastroenterology, vol.153, issue.6, pp.1621-1633, 2017.

A. M. Thomas, P. Manghi, F. Asnicar, E. Pasolli, F. Armanini et al.,

N. Manara, C. Karcher, S. Pozzi, D. Gandini, S. Serrano et al., , p.691

M. Trompetto, G. Ferrero, S. Mizutani, H. Shiroma, S. Shiba et al.,

J. Yamada, P. Wirbel, C. M. Schrotz-king, H. Ulrich, M. Brenner et al.,

F. Zeller, E. Cordero, J. C. Dias-neto, A. Setubal, B. Tett et al., , p.694

A. Naccarati and N. Segata, Metagenomic analysis of colorectal cancer datasets identifies cross-695 cohort microbial diagnostic signatures and a link with choline degradation, Nat Med, vol.696, issue.4, pp.667-678, 2019.

J. Wirbel, P. T. Pyl, E. Kartal, K. Zych, A. Kashani et al., , p.698

A. Palleja, R. Ponnudurai, S. Sunagawa, L. P. Coelho, P. Schrotz-king et al.,

E. Habermann, A. M. Niméus, P. Thomas, S. Manghi, D. Gandini et al.,

S. Shiroma, T. Shiba, S. Shibata, T. Yachida, L. Yamada et al., , p.701

R. Sinha, C. M. Ulrich, H. Brenner, M. Arumugam, P. Bork et al., Meta-analysis of fecal 702 metagenomes reveals global microbial signatures that are specific for colorectal cancer

. Med, , vol.25, pp.679-689, 2019.

R. V. Purcell, M. Visnovska, P. J. Biggs, S. Schmeier, and F. A. Frizelle, Distinct gut 706 microbiome patterns associate with consensus molecular subtypes of colorectal cancer, Sci 707 Rep, vol.7, issue.1, p.11590, 2017.

, Invasive carcinoma or carcinoma in situ of any aspect in the rectum or colon=CRC; controls= normal colonoscopy. b Student's t test and chi-square test for continuous and binary variables, respectively. *adjusted for age, gender and all variables listed in the table; ?Positivity cutoffs were 2.0 for the CMI and 150 ng/mL for the FIT; OR, odds ratio, a The cohort included 981 individuals from two different cohorts