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Journal articles
Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists
Genelle Harrison
1, 2
Joaquin Sanz
2, 3
Jonathan Boulais
2, 3
Michael Mina
4
Jean-Christophe Grenier
2
Yumei Leng
5
Anne Dumaine
2
Vania Yotova
2
Christina Bergey
6
Samuel Nsobya
7
Stephen Elledge
5
Erwin Schurr
1
Lluis Quintana-Murci
8, 9
George Perry
6
Luis Barreiro
2, 3, 10
Genelle F. Harrison 1, 2
Author
Joaquin Sanz 2, 3
Author
Jonathan Boulais 2, 3
Author
Michael Mina 4
Author
1
MUHC - McGill University Health Center [Montreal] (1001 Décarie Boulevard, Montreal, QC H4A 3J1 - Canada)
2
CHU Sainte Justine [Montréal] (3175, Chemin de la Côte-Sainte-Catherine, Montréal H3T 1C5, Québec - Canada)
3
UdeM - Université de Montréal (2900 Boulevard Edouard-Montpetit, Montréal, QC H3T 1J4 - Canada)
4
Brigham and Women's Hospital [Boston] (75 Francis St, Boston, MA 02115 - United States)
5
HHMI - Howard Hughes Medical Institute [Boston] (Harvard Medical School Boston, Massachusetts 02115 - United States)
- HHMI - Howard Hughes Medical Institute (United States)
- HMS - Harvard Medical School [Boston] (25 Shattuck Street Boston, MA 02115 - United States)
6
Penn State - Pennsylvania State University (201 Old Main, University Park, Pennsylvania 16802 - United States)
- Penn State System (Pennsylvania, PA, USA, Etats-Unis - United States)
7
MAK - Makerere University [Kampala, Ouganda] (P.O. Box 7062 - Kampala - Uganda)
8
Génétique Evolutive Humaine - Human Evolutionary Genetics (Département Génomes et Génétique - 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR2000 (France)
9
C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative (25-28 rue du docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : USR3756 (France)
10
University of Chicago (Edward H. Levi Hall 5801 South Ellis Avenue Chicago, Illinois 60637 - United States)
Abstract : The shift from a hunter-gatherer to an agricultural mode of subsistence is believed to have been associated with profound changes in the burden and diversity of pathogens across human populations. Yet, the extent to which the advent of agriculture affected the evolution of the human immune system remains unknown. Here we present a comparative study of variation in the transcriptional responses of peripheral blood mononuclear cells to bacterial and viral stimuli between Batwa rainforest hunter-gatherers and Bakiga agriculturalists from Uganda. We observed increased divergence between hunter-gatherers and agriculturalists in the early transcriptional response to viruses compared with that for bacterial stimuli. We demonstrate that a significant fraction of these transcriptional differences are under genetic control and we show that positive natural selection has helped to shape population differences in immune regulation. Across the set of genetic variants underlying inter-population immune-response differences, however, the signatures of positive selection were disproportionately observed in the rainforest hunter-gatherers. This result is counter to expectations on the basis of the popularized notion that shifts in pathogen exposure due to the advent of agriculture imposed radically heightened selective pressures in agriculturalist populations.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02549704
Contributor : Lluis Quintana-Murci <>
Submitted on : Tuesday, April 21, 2020 - 4:37:14 PM
Last modification on : Thursday, February 25, 2021 - 6:56:01 PM
Contributor : Lluis Quintana-Murci <>
Submitted on : Tuesday, April 21, 2020 - 4:37:14 PM
Last modification on : Thursday, February 25, 2021 - 6:56:01 PM
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Identifiers
- HAL Id : pasteur-02549704, version 1
- DOI : 10.1038/s41559-019-0947-6
- PUBMED : 31358949
- PUBMEDCENTRAL : PMC6684323
Citation
Genelle Harrison, Joaquin Sanz, Jonathan Boulais, Michael Mina, Jean-Christophe Grenier, et al.. Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists. Nature Ecology & Evolution, Nature, 2019, 3 (8), pp.1253-1264. ⟨10.1038/s41559-019-0947-6⟩. ⟨pasteur-02549704⟩
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