A LIVE AND ATTENUATED FLAVIVIRUS COMPRISING A MUTATED M PROTEIN FIELD OF THE INVENTION 5 BACKGROUND OF THE INVENTION - Archive ouverte HAL Access content directly
Patents Year : 2019

A LIVE AND ATTENUATED FLAVIVIRUS COMPRISING A MUTATED M PROTEIN FIELD OF THE INVENTION 5 BACKGROUND OF THE INVENTION

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Abstract

The application relates to the attenuation of flaviviruses, such as West Nile Virus (WNV). The application notably provides a live and attenuated flavivirus, such as a WNV, comprising a mutated M protein. Said mutated M protein comprises or consists of a sequence, wherein the amino acids at position 36 in the ectodomain and position 43 in the transmembrane 10 domain 1 in said sequence are mutated. The application also provides additional embodiments deriving from said live and attenuated flavivirus, such as a WNV, such as nucleic acids, cDNA clones, immunogenic compositions as well as uses and methods.
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Dates and versions

pasteur-02549215 , version 1 (21-04-2020)

Identifiers

  • HAL Id : pasteur-02549215 , version 1

Cite

Nathalie Pardigon, Felix Rey, Justine Basset. A LIVE AND ATTENUATED FLAVIVIRUS COMPRISING A MUTATED M PROTEIN FIELD OF THE INVENTION 5 BACKGROUND OF THE INVENTION. United States, Patent n° : US 62/825,734. 2019. ⟨pasteur-02549215⟩
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