A LIVE AND ATTENUATED FLAVIVIRUS COMPRISING A MUTATED M PROTEIN FIELD OF THE INVENTION 5 BACKGROUND OF THE INVENTION

Nathalie Pardigon (1) , Felix Rey (2) , Justine Basset (1, 3)

1 ERI - Environnement et Risques infectieux - Environment and Infectious Risks
2 Virologie Structurale - Structural Virology
3 Cellule Pasteur

The application relates to the attenuation of flaviviruses, such as West Nile Virus (WNV). The application notably provides a live and attenuated flavivirus, such as a WNV, comprising a mutated M protein. Said mutated M protein comprises or consists of a sequence, wherein the amino acids at position 36 in the ectodomain and position 43 in the transmembrane 10 domain 1 in said sequence are mutated. The application also provides additional embodiments deriving from said live and attenuated flavivirus, such as a WNV, such as nucleic acids, cDNA clones, immunogenic compositions as well as uses and methods.

Domaines: Virologie

Nathalie Pardigon, Felix Rey, Justine Basset. A LIVE AND ATTENUATED FLAVIVIRUS COMPRISING A MUTATED M PROTEIN FIELD OF THE INVENTION 5 BACKGROUND OF THE INVENTION. United States, Patent n° : US 62/825,734. 2019. ⟨pasteur-02549215⟩