Human Immunology through the Lens of Evolutionary Genetics - Archive ouverte HAL Access content directly
Journal Articles Cell Year : 2019

Human Immunology through the Lens of Evolutionary Genetics

(1)
1

Abstract

Pathogen-imposed selection pressures have been paramount during human evolution. Detecting such selection signatures in ancient and modern human genomes can thus help us to identify genes of temporal and spatial immunological relevance. Admixture with ancient hominins and between human populations has been a source of genetic diversity open to selection by infections. Furthermore, cultural transitions, such as the advent of agriculture, have exposed humans to new microbial threats, with impacts on host defense mechanisms. The integration of population genetics and systems immunology holds great promise for the increased understanding of the factors driving immune response variation between individuals and populations.
Fichier principal
Vignette du fichier
Cell_Quintana-Murci_review_2019.pdf (2.23 Mo) Télécharger le fichier
Loading...

Dates and versions

pasteur-02549185 , version 1 (21-04-2020)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

Identifiers

Cite

Lluis Quintana-Murci. Human Immunology through the Lens of Evolutionary Genetics. Cell, 2019, 177 (1), pp.184-199. ⟨10.1016/j.cell.2019.02.033⟩. ⟨pasteur-02549185⟩
42 View
94 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More