Reconciling the chemistry and biology of reactive oxygen species, Nat. Chem. Biol, vol.4, pp.278-286, 2008. ,
Reactive oxygen species in phagocytic leukocytes, Histochem. Cell Biol, vol.130, pp.281-297, 2008. ,
Peroxide-sensing transcriptional regulators in bacteria, J. Bacteriol, vol.194, pp.5495-5503, 2012. ,
Hydrogen peroxide sensing in Bacillus subtilis: it is all about the (metallo)regulator, Mol. Microbiol, vol.73, pp.1-4, 2009. ,
Regulation of the Bacillus subtilis fur and perR genes by PerR: not all members of the PerR regulon are peroxide inducible, J. Bacteriol, vol.184, pp.3276-3286, 2002. ,
Structural characterization of the active form of PerR: insights into the metal-induced activation of PerR and Fur proteins for DNA binding, Mol. Microbiol, vol.73, pp.20-31, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00730670
Biochemical characterization of the structural Zn 2? site in the Bacillus subtilis peroxide sensor PerR, J. Biol. Chem, vol.281, pp.23567-23578, 2006. ,
Crystal structure of the apo-PerR-Zn protein from Bacillus subtilis, Mol. Microbiol, vol.61, pp.1211-1219, 2006. ,
The PerR transcription factor senses H 2 O 2 by metal-catalysed histidine oxidation, Nature, vol.440, pp.363-367, 2006. ,
Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein, Nat. Chem. Biol, vol.5, pp.53-59, 2009. ,
Reaction of PerR with molecular oxygen may assist H 2 O 2 sensing in anaerobes, ACS Chem. Biol, vol.11, pp.1438-1444, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01345260
Transcriptional response of Leptospira interrogans to iron limitation and characterization of a PerR homolog, Infect. Immun, vol.78, pp.4850-4859, 2010. ,
Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen, Nat. Rev. Microbiol, vol.7, pp.736-747, 2009. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00450871
Virulence of the zoonotic agent of leptospirosis: still terra incognita?, Nat. Rev. Microbiol, vol.15, pp.297-307, 2017. ,
Pathogenesis of leptospirosis: cellular and molecular aspects, Vet. Microbiol, vol.172, pp.353-358, 2014. ,
Leptospirosis in humans, Curr. Top. Microbiol. Immunol, vol.387, pp.65-97, 2015. ,
Global morbidity and mortality of leptospirosis: a systematic review, PLoS Negl. Trop. Dis, vol.9, 2015. ,
Production of reactive oxygen species and expression of inducible nitric oxide synthase in rat isolated Kupffer cells stimulated by Leptospira interrogans and Borrelia burgdorferi, World J. Gastroenterol, vol.12, pp.3077-3081, 2006. ,
Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis, Am J. Trop. Med. Hyg, vol.90, pp.719-723, 2014. ,
Serum sialic acid and oxidative stress parameters changes in cattle with leptospirosis, Vet. Res. Commun, vol.32, pp.333-339, 2008. ,
Hydrogen peroxide in human urine: implications for antioxidant defense and redox regulation, Biochem. Biophys. Res. Commun, vol.262, pp.605-609, 1999. ,
Production of reactive oxygen species by tubular epithelial cells in culture, Kidney Int, vol.37, pp.1509-1514, 1990. ,
Hydrogen peroxide and sodium transport in the lung and kidney, Biomed. Res. Int, p.9512807, 2016. ,
,
Leptospira interrogans catalase is required for resistance to H 2 O 2 and for virulence, Infect. Immun, vol.11, pp.3892-3899, 2012. ,
A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni, PLoS Pathog, vol.10, 2014. ,
Crystal structure of peroxide stress regulator from Streptococcus pyogenes provides functional insights into the mechanism of oxidative stress sensing, J. Biol. Chem, vol.288, pp.18311-18324, 2013. ,
Distinct structural features of the peroxide response regulator from group A Streptococcus drive DNA binding, PLoS One, vol.9, 2014. ,
Genome-wide transcriptional start site mapping and sRNA identification in the pathogen Leptospira interrogans, Front. Cell Infect. Microbiol, vol.7, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02545870
Nutrition of Leptospira pomona and growth of 13 other serotypes: fractionation of oleic albumin complex and a medium of bovine albumin and polysorbate 80, Am. J. Vet. Res, vol.26, pp.45-51, 1965. ,
A replicative plasmid vector allows efficient complementation of pathogenic Leptospira strains, Appl. Environ. Microbiol, vol.81, pp.3176-3181, 2015. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02536538
The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites, Mol. Microbiol, vol.79, pp.1260-1275, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00936385
Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator, Mol. Microbiol, vol.47, pp.903-915, 2003. ,
Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination, Mol. Microbiol, vol.72, 2009. ,
Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR. Proc. Natl. Acad. Sci. U.S.A, vol.113, 2016. ,
Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator, Nat. Commun, vol.6, p.7642, 2015. ,
,
The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes, Mol. Microbiol, vol.55, pp.221-234, 2005. ,
Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors, Mol. Microbiol, vol.29, pp.189-198, 1998. ,
dpr and sod in Streptococcus mutans are involved in coexistence with S. sanguinis, and PerR is associated with resistance to H 2 O 2, Appl. Environ. Microbiol, vol.79, pp.1436-1443, 2013. ,
PerR acts as a switch for oxygen tolerance in the strict anaerobe Clostridium acetobutylicum, Mol. Microbiol, vol.68, pp.848-860, 2008. ,
PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus, Infect Immun, vol.69, pp.3744-3754, 2001. ,
Campylobacter jejuni contains two fur homologs: characterization of iron-responsive regulation of peroxide stress defense genes by the PerR repressor, J. Bacteriol, vol.181, pp.6371-6376, 1999. ,
PerR confers phagocytic killing resistance and allows pharyngeal colonization by group A Streptococcus, PLoS Pathog, vol.4, 2008. ,
Characterization of the oxidative stress stimulon and PerR regulon of Campylobacter jejuni, BMC Genomics, vol.10, p.481, 2009. ,
Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence, Appl. Environ. Microbiol, vol.71, pp.8314-8322, 2005. ,
The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes, Infect. Immun, vol.70, pp.4968-4976, 2002. ,
A Fur-like protein PerR regulates two oxidative stress response related operons dpr and metQIN in Streptococcus suis, BMC Microbiol, vol.12, p.85, 2012. ,
,
Differential secretomics of Streptococcus pyogenes reveals a novel peroxide regulator (PerR)-regulated extracellular virulence factor mitogen factor 3 (MF3), Mol. Cell Proteomics, vol.10, 2011. ,
CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria, Mol. Microbiol, vol.31, pp.117-131, 1999. ,
Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus, J. Bacteriol, vol.186, pp.1175-1181, 2004. ,
, Acta Crystallogr. D Biol. Crystallogr, vol.66, pp.125-132, 2010.
A short history of SHELX, Acta Crystallogr. A, vol.64, pp.112-122, 2008. ,
Phaser crystallographic software, J. Appl. Crystallogr, vol.40, pp.658-674, 2007. ,
Overview of the CCP4 suite and current developments, Acta Crystallogr. D Biol. Crystallogr, vol.67, pp.235-242, 2011. ,
Features and development of Coot, Acta Crystallogr D Biol. Crystallogr, vol.66, pp.486-501, 2010. ,
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT, Acta Crystallogr. D Biol. Crystallogr, vol.60, pp.2210-2221, 2004. ,
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER, Acta Crystallogr. D Biol. Crystallogr, vol.68, pp.368-380, 2012. ,
The PyMOL Molecular Graphics System, version 1.3r1, Schrödinger, LLC, New York Characterization of the Leptospira peroxide stress regulator, J. Biol. Chem, vol.293, issue.2, pp.497-509, 2010. ,