Recurrent episodes of Candidemia due to Candida glabrata, Candida tropicalis and Candida albicans with acquired echinocandin resistance

Marine Grosset (1) , Marie Desnos-Ollivier (2, 3) , Cendrine Godet (1) , Catherine Kauffmann-Lacroix (4) , France Cazenave-Roblot (1)

1 Unité Maladies Infectieuses et tropicales [CHU Poitiers]
2 Mycologie moléculaire - Molecular Mycology
3 CNRMA - Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire
4 CHU Poitiers - Centre hospitalier universitaire de Poitiers

Mixed fungal infection and acquired echinocandin resistance of Candida spp. remain infrequent. In this study we have reported the case of a patient hospitalized for tuberculosis who experienced multiple infections due to three common Candida species (C. albicans, C. glabrata, C. tropicalis). Furthermore, consecutive isolates from blood cultures and heart valve were found resistant to azoles (C. tropicalis) and to echinocandin with either novel (C. tropicalis) or previously described (C. albicans) missense mutations in the Fks gene.

Keywords: Candidemia; Echinocandin resistance; Endocarditis; Fks mutation; Mixed infection; Multiresistance

Domains: Mycology

Marine Grosset, Marie Desnos-Ollivier, Cendrine Godet, Catherine Kauffmann-Lacroix, France Cazenave-Roblot. Recurrent episodes of Candidemia due to Candida glabrata, Candida tropicalis and Candida albicans with acquired echinocandin resistance. Medical Mycology Case Reports, 2016, 14, pp.20-23. ⟨10.1016/j.mmcr.2016.12.004⟩. ⟨pasteur-02548422⟩